Detailed information of TA system TA195204

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 676907..677165
• Replicon: chromosome
• Accession: NZ_CP071073
• Organism: Escherichia coli strain 3347558

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JY392_RS03305
• Protein ID: WP_000809168.1
• Coordinates: 676907..677059 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	677108..677165 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY392_RS03290	672319..674235	+	1917	WP_000516135.1	molecular chaperone DnaK	-
JY392_RS03295	674324..675454	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
JY392_RS03300	675717..676829	-	1113	WP_001300563.1	IS4-like element IS421 family transposase	-
JY392_RS03305	676907..677059	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	677108..677165	+	58	-	-	Antitoxin
JY392_RS03310	677645..678811	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
JY392_RS03315	678877..679776	+	900	WP_001300855.1	transcriptional activator NhaR	-
JY392_RS03320	679814..680773	-	960	WP_000871674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	espX1	675717..686237	10520

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T195204 WP_000809168.1 NZ_CP071073:c677059-676907 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T195204 NZ_CP094359:647384-647635 [Acidithiobacillus sp. YTS05]
ATGGATGCCATCACCTATAGTACCGCTCGAGCCAAGTTAGCCGATACCATGGATCGTGTCTGCGATGATCACGAGCCCAT
CATCATTACGCGCAACGGGGAGCAAGCCGTGGTGATGATGTCGCTTGAGGACTTCAAGGCCCTTGAAGAGACGTCTTATT
TGCTCAGGAGCCCGAAGAACGCAAAGCGATTACTGGAGAGCATTGCGTCGCTGGAATCGGGGAGGGGCAAGGCCAGGAAT
CTTGCCGAGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT195204 NZ_CP071073:677108-677165 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin