Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3734212..3734869 Replicon chromosome
Accession NZ_CP071015
Organism Enterobacter hormaechei strain RIVM_C019181

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JQL71_RS17730 Protein ID WP_022649305.1
Coordinates 3734212..3734622 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JQL71_RS17735 Protein ID WP_003863437.1
Coordinates 3734603..3734869 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL71_RS17710 3730210..3731943 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
JQL71_RS17715 3731949..3732662 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JQL71_RS17720 3732691..3733587 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JQL71_RS17725 3733689..3734210 + 522 WP_015571793.1 flavodoxin FldB -
JQL71_RS17730 3734212..3734622 - 411 WP_022649305.1 protein YgfX Toxin
JQL71_RS17735 3734603..3734869 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JQL71_RS17740 3735164..3736144 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JQL71_RS17745 3736668..3737327 - 660 WP_022649307.1 hemolysin III family protein -
JQL71_RS17750 3737594..3738325 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T195030 WP_022649305.1 NZ_CP071015:c3734622-3734212 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T195030 NZ_CP094283:c2285236-2285054 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT195030 WP_003863437.1 NZ_CP071015:c3734869-3734603 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT195030 NZ_CP094283:c2284961-2284557 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References