Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3827159..3827940 Replicon chromosome
Accession NZ_CP071013
Organism Enterobacter hormaechei strain RIVM_C033144

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag JQL76_RS18220 Protein ID WP_022649378.1
Coordinates 3827159..3827650 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag JQL76_RS18225 Protein ID WP_022649379.1
Coordinates 3827647..3827940 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL76_RS18205 3822439..3822891 - 453 WP_022649375.1 hypothetical protein -
JQL76_RS18210 3823406..3825316 + 1911 WP_022649376.1 hypothetical protein -
JQL76_RS18215 3825313..3827007 + 1695 WP_022649377.1 hypothetical protein -
JQL76_RS18220 3827159..3827650 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
JQL76_RS18225 3827647..3827940 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
JQL76_RS18230 3828042..3829835 - 1794 WP_022649380.1 hybrid sensor histidine kinase/response regulator -
JQL76_RS18235 3829832..3830464 - 633 WP_022649381.1 response regulator transcription factor -
JQL76_RS18240 3830640..3830954 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T195015 WP_022649378.1 NZ_CP071013:c3827650-3827159 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

>T195015 NZ_CP094275:c43955-43698 [Klebsiella aerogenes]
ATGAAAAAGTCAAAGGGTGATGCTCAATATTATCTTGAGAAGGAAGGTGATATATATCACCTTGTCAAAAGAGTTAAAAC
ATTCTCAAAAAAATTGACTCAGGGTAAAACGAAAGCAACAACGAAAACGGTCAGTGACTTTAGTTTTACTAAAAATAATT
TCGAGGATATAGATTTTAATGCAAATGGTTTAAGGGAGAAAGATAAGTCAATAATTGTTCAGATGGTTGAAGAAATCGAG
GGGCTACATGCTGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT195015 WP_022649379.1 NZ_CP071013:c3827940-3827647 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp

>AT195015 NZ_CP094275:c43708-43475 [Klebsiella aerogenes]
ATGCTGATTAATACGCCTGAAAACATCAAAATTTTGCGAAAAAAAATAGGGCTAACGCAGAAAGAATGTGCGGAAATGTT
CGGAATGACCGCGCGATCATGGCGGCGTAAGGAAGAACCACAAACGACAGCCAGCAATACAACACTATCGCCAATAGAAT
TTAACTATCTTTTGTTACTGGCTGGCGAGCATCCTGATTATGTTTTGTGCAAGCGCGAGGCATTGCACCCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References