Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2279497..2280236 Replicon chromosome
Accession NZ_CP071013
Organism Enterobacter hormaechei strain RIVM_C033144

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag JQL76_RS10990 Protein ID WP_022648141.1
Coordinates 2279497..2279982 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag JQL76_RS10995 Protein ID WP_003857131.1
Coordinates 2279970..2280236 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQL76_RS10960 2275546..2275806 + 261 WP_206215745.1 SDR family NAD(P)-dependent oxidoreductase -
JQL76_RS10970 2276864..2277535 + 672 WP_206215746.1 SDR family oxidoreductase -
JQL76_RS10975 2278184..2278465 + 282 Protein_2138 DUF4225 domain-containing protein -
JQL76_RS10980 2278440..2278769 - 330 WP_022648139.1 hypothetical protein -
JQL76_RS10985 2278902..2279471 + 570 WP_022648140.1 hypothetical protein -
JQL76_RS10990 2279497..2279982 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
JQL76_RS10995 2279970..2280236 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
JQL76_RS11000 2280300..2281229 - 930 WP_022648142.1 LysR family transcriptional regulator -
JQL76_RS11005 2281359..2282747 + 1389 WP_022648143.1 MFS transporter -
JQL76_RS11010 2282726..2283283 - 558 WP_022648144.1 OmpH family outer membrane protein -
JQL76_RS11015 2283404..2284540 - 1137 WP_022648145.1 type 1 fimbrial protein -
JQL76_RS11020 2284564..2285088 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2255405..2280236 24831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T195004 WP_022648141.1 NZ_CP071013:c2279982-2279497 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T195004 NZ_CP094272:861167-861577 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT195004 WP_003857131.1 NZ_CP071013:c2280236-2279970 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT195004 NZ_CP094272:860920-861186 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References