Detailed information of TA system TA194950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1638538..1639055
• Replicon: chromosome
• Accession: NZ_CP070991
• Organism: Staphylococcus aureus strain CBS2016-05

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A2C9TUQ6
• Locus tag: JYA46_RS08315
• Protein ID: WP_033863183.1
• Coordinates: 1638538..1638843 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A2B8BQK3
• Locus tag: JYA46_RS08320
• Protein ID: WP_001058490.1
• Coordinates: 1638846..1639055 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA46_RS08290 (1634184)	1634184..1634525	-	342	WP_001190614.1	hypothetical protein	-
JYA46_RS08295 (1634974)	1634974..1635615	-	642	WP_072490956.1	pathogenicity island protein	-
JYA46_RS08300 (1635617)	1635617..1635889	-	273	WP_001149387.1	hypothetical protein	-
JYA46_RS08305 (1635876)	1635876..1636679	-	804	WP_033863177.1	bifunctional DNA primase/polymerase	-
JYA46_RS08310 (1636850)	1636850..1638463	-	1614	WP_106875302.1	phage resistance protein	-
JYA46_RS08315 (1638538)	1638538..1638843	-	306	WP_033863183.1	DUF1474 family protein	Toxin
JYA46_RS08320 (1638846)	1638846..1639055	-	210	WP_001058490.1	hypothetical protein	Antitoxin
JYA46_RS08325 (1639048)	1639048..1639194	-	147	WP_000784873.1	hypothetical protein	-
JYA46_RS08330 (1639206)	1639206..1639478	-	273	WP_001138301.1	helix-turn-helix domain-containing protein	-
JYA46_RS08335 (1639479)	1639479..1639691	-	213	WP_033863184.1	helix-turn-helix transcriptional regulator	-
JYA46_RS08340 (1639730)	1639730..1639930	-	201	WP_001033058.1	helix-turn-helix domain-containing protein	-
JYA46_RS08345 (1640037)	1640037..1640960	+	924	WP_050436923.1	helix-turn-helix transcriptional regulator	-
JYA46_RS08350 (1640986)	1640986..1642195	+	1210	Protein_1608	tyrosine-type recombinase/integrase	-
JYA46_RS08355 (1642197)	1642197..1643096	+	900	WP_001797289.1	Abi family protein	-
JYA46_RS08360 (1643335)	1643335..1643577	-	243	WP_000897044.1	30S ribosomal protein S18	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1623467..1648192	24725

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12172.46 Da
• Isoelectric Point: 4.4054

>T194950 WP_033863183.1 NZ_CP070991:c1638843-1638538 [Staphylococcus aureus]
MNLEIKDLFSDLKLLKDRFEDLKDNHGWHFEELYPHEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDA

Nucleotide

• Length: 306 bp

>T194950 NZ_CP094237:c5335303-5334920 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8153.17 Da
• Isoelectric Point: 4.3591

>AT194950 WP_001058490.1 NZ_CP070991:c1639055-1638846 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLGKGE

Nucleotide

• Length: 210 bp

>AT194950 NZ_CP094237:c5335545-5335303 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A2C9TUQ6

Antitoxin

• AlphaFold DB: A0A2B8BQK3