Detailed information of TA system TA194898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2550035..2550645
• Replicon: chromosome
• Accession: NZ_CP070980
• Organism: Pseudomonas rhodesiae strain AAMF24

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2G0WYT7
• Locus tag: JYG35_RS11655
• Protein ID: WP_034096965.1
• Coordinates: 2550394..2550645 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JYG35_RS11650
• Protein ID: WP_034096964.1
• Coordinates: 2550035..2550397 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG35_RS11630 (JYG35_11630)	2545255..2546283	-	1029	WP_034096960.1	ABC transporter ATP-binding protein	-
JYG35_RS11635 (JYG35_11635)	2546527..2547357	+	831	WP_213549373.1	IclR family transcriptional regulator	-
JYG35_RS11640 (JYG35_11640)	2547461..2548816	+	1356	WP_034096962.1	MATE family efflux transporter	-
JYG35_RS11645 (JYG35_11645)	2548858..2550030	+	1173	WP_047883050.1	MFS transporter	-
JYG35_RS11650 (JYG35_11650)	2550035..2550397	-	363	WP_034096964.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JYG35_RS11655 (JYG35_11655)	2550394..2550645	-	252	WP_034096965.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9497.05 Da
• Isoelectric Point: 10.0458

>T194898 WP_034096965.1 NZ_CP070980:c2550645-2550394 [Pseudomonas rhodesiae]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDSGDPTAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T194898 NZ_CP094165:717859-718131 [Helicobacter pylori]
ATGCCGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGTTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13134.99 Da
• Isoelectric Point: 7.0377

>AT194898 WP_034096964.1 NZ_CP070980:c2550397-2550035 [Pseudomonas rhodesiae]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALISYEGKTVADLDAAFQAAVDDYLVTCQNLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALSEFLQHHFAELHPSA

Nucleotide

• Length: 363 bp

>AT194898 NZ_CP094165:717561-717872 [Helicobacter pylori]
ATGCCTAACTCTCCCGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCCCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCCGATGATTGA

Structures

Toxin

• AlphaFold DB: A0A2G0WYT7