Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4189098..4189933 Replicon chromosome
Accession NZ_CP070930
Organism Escherichia coli strain 30COLEC

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag JR883_RS20105 Protein ID WP_000854821.1
Coordinates 4189556..4189933 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A4Q1HU91
Locus tag JR883_RS20100 Protein ID WP_053287563.1
Coordinates 4189098..4189466 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR883_RS20070 4184125..4185144 + 1020 WP_071702264.1 transcriptional regulator -
JR883_RS20075 4185254..4186126 + 873 WP_063122478.1 GTPase family protein -
JR883_RS20080 4186843..4187661 + 819 WP_001234702.1 DUF945 domain-containing protein -
JR883_RS20085 4187752..4188237 + 486 WP_000214317.1 antirestriction protein -
JR883_RS20090 4188252..4188728 + 477 WP_001186747.1 RadC family protein -
JR883_RS20095 4188797..4189018 + 222 WP_000692312.1 DUF987 domain-containing protein -
JR883_RS20100 4189098..4189466 + 369 WP_053287563.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JR883_RS20105 4189556..4189933 + 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
JR883_RS20110 4189930..4190127 + 198 Protein_3925 hypothetical protein -
JR883_RS20115 4190155..4190352 + 198 WP_023563519.1 DUF957 domain-containing protein -
JR883_RS20120 4190437..4191279 + 843 WP_071701699.1 DUF4942 domain-containing protein -
JR883_RS20125 4192028..4193566 + 1539 WP_074477856.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4184125..4201378 17253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T194723 WP_000854821.1 NZ_CP070930:4189556-4189933 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T194723 NZ_CP093935:c2501280-2501014 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.36 Da        Isoelectric Point: 6.4768

>AT194723 WP_053287563.1 NZ_CP070930:4189098-4189466 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT194723 NZ_CP093935:c2501531-2501280 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q1HU91

References