Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3057936..3058641 Replicon chromosome
Accession NZ_CP070930
Organism Escherichia coli strain 30COLEC

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JR883_RS14700 Protein ID WP_000539521.1
Coordinates 3057936..3058322 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JR883_RS14705 Protein ID WP_001280945.1
Coordinates 3058312..3058641 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR883_RS14680 3053940..3054566 + 627 WP_001295292.1 glutathione S-transferase GstB -
JR883_RS14685 3054563..3055678 - 1116 WP_205899493.1 PQQ-dependent sugar dehydrogenase -
JR883_RS14690 3055789..3056172 - 384 WP_000497137.1 biofilm formation regulator BssR -
JR883_RS14695 3056385..3057710 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JR883_RS14700 3057936..3058322 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR883_RS14705 3058312..3058641 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JR883_RS14710 3058711..3060039 - 1329 WP_000086877.1 GGDEF domain-containing protein -
JR883_RS14715 3060047..3062395 - 2349 WP_061359889.1 EAL domain-containing protein -
JR883_RS14720 3062573..3063484 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T194717 WP_000539521.1 NZ_CP070930:3057936-3058322 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T194717 NZ_CP093935:1908243-1908338 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT194717 WP_001280945.1 NZ_CP070930:3058312-3058641 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT194717 NZ_CP093935:c1908423-1908366 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References