Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 378978..379813 Replicon chromosome
Accession NZ_CP070593
Organism Escherichia coli strain ESC53083

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag JW305_RS03135 Protein ID WP_000854759.1
Coordinates 379436..379813 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag JW305_RS03130 Protein ID WP_001295723.1
Coordinates 378978..379346 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW305_RS03105 376093..376251 + 159 WP_001323397.1 DUF905 family protein -
JW305_RS03110 376406..377224 + 819 WP_001234738.1 DUF945 domain-containing protein -
JW305_RS03115 377566..378039 + 474 WP_001350782.1 antirestriction protein -
JW305_RS03120 378055..378531 + 477 WP_001186775.1 RadC family protein -
JW305_RS03125 378594..378815 + 222 WP_000692345.1 DUF987 domain-containing protein -
JW305_RS03130 378978..379346 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JW305_RS03135 379436..379813 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
JW305_RS03140 379810..380298 + 489 WP_000761690.1 hypothetical protein -
JW305_RS03145 380315..380491 + 177 WP_000839286.1 DUF957 domain-containing protein -
JW305_RS03150 380591..380749 + 159 WP_001467148.1 hypothetical protein -
JW305_RS03155 381113..381289 + 177 Protein_351 helix-turn-helix domain-containing protein -
JW305_RS03160 382062..383702 + 1641 WP_001332039.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T194437 WP_000854759.1 NZ_CP070593:379436-379813 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T194437 NZ_CP093485:c23588-23337 [Klebsiella pneumoniae]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT194437 WP_001295723.1 NZ_CP070593:378978-379346 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT194437 NZ_CP093485:c23350-23123 [Klebsiella pneumoniae]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References