Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4719544..4720201 Replicon chromosome
Accession NZ_CP070534
Organism Enterobacter hormaechei strain EC48293

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag JW293_RS24560 Protein ID WP_017382887.1
Coordinates 4719544..4719954 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JW293_RS24565 Protein ID WP_003863437.1
Coordinates 4719935..4720201 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW293_RS24540 4715542..4717275 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
JW293_RS24545 4717281..4717994 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW293_RS24550 4718023..4718919 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
JW293_RS24555 4719021..4719542 + 522 WP_032649423.1 flavodoxin FldB -
JW293_RS24560 4719544..4719954 - 411 WP_017382887.1 protein YgfX Toxin
JW293_RS24565 4719935..4720201 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JW293_RS24570 4720496..4721476 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
JW293_RS24575 4721588..4722247 - 660 WP_003863433.1 hemolysin III family protein -
JW293_RS24580 4722514..4723245 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
JW293_RS24585 4723362..4724795 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T194299 WP_017382887.1 NZ_CP070534:c4719954-4719544 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T194299 NZ_CP093405:2783504-2783815 [Salmonella enterica subsp. enterica serovar Agona]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAAAGATTTCTCTTCTCCGGCAGAGCTACGAACGGTCATACCGAGCCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTATTACAGGGAGAATAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT194299 WP_003863437.1 NZ_CP070534:c4720201-4719935 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT194299 NZ_CP093405:2783812-2784231 [Salmonella enterica subsp. enterica serovar Agona]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTGGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGCGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References