Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5716949..5717577 Replicon chromosome
Accession NZ_CP070503
Organism Pseudomonas atacamensis strain SM1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JWU58_RS25855 Protein ID WP_206421226.1
Coordinates 5717179..5717577 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JWU58_RS25850 Protein ID WP_076565118.1
Coordinates 5716949..5717179 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWU58_RS25825 5713156..5713470 + 315 WP_206421224.1 hypothetical protein -
JWU58_RS25830 5713781..5714839 + 1059 WP_206422226.1 DUF1016 family protein -
JWU58_RS25835 5714931..5715881 + 951 WP_206421225.1 alpha/beta fold hydrolase -
JWU58_RS25840 5715911..5716324 + 414 WP_016772137.1 hypothetical protein -
JWU58_RS25845 5716331..5716783 + 453 WP_016772138.1 hypothetical protein -
JWU58_RS25850 5716949..5717179 + 231 WP_076565118.1 antitoxin Antitoxin
JWU58_RS25855 5717179..5717577 + 399 WP_206421226.1 tRNA(fMet)-specific endonuclease VapC Toxin
JWU58_RS25860 5717655..5719046 - 1392 WP_151551241.1 GABA permease -
JWU58_RS25865 5719590..5720363 + 774 WP_024011209.1 ABC transporter ATP-binding protein -
JWU58_RS25870 5720377..5721129 + 753 WP_024011208.1 ABC transporter substrate-binding protein -
JWU58_RS25875 5721207..5721902 + 696 WP_122705208.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14533.89 Da        Isoelectric Point: 7.1340

>T194210 WP_206421226.1 NZ_CP070503:5717179-5717577 [Pseudomonas atacamensis]
MIKYMLDTNICIFTIKNKPQIVREAFNRHSGQLCISAITLMELIYGAEKSAAPEKNLGIVEGFVARLDVLPFDNDAAAQA
GMVRSELAKAGTPIGPYDQMIAGHARSLGLIVVTNNVREFQRVSGLRIEDWV

Download         Length: 399 bp

>T194210 NZ_CP093390:c2121126-2120848 [Salmonella enterica]
ATGATTAAAAGCTTCAGACATAAGGGACTGAAAAAGTTCTATCAAAAAGGCGACAGCAGCGGTTTAGAACAATCACTGGT
CCCGCGCCTGAAAAACAGGTTATCCATGCTGGATGCAGCAAAGACAATTGATTTCCTGAATCAGCAAGGCTACGACCTTC
ATGAGCTTAAAGGCGATCGTGCTGAAACGTGGTCCATAAAAGTTTCTGGTAACTGGCGTCTGACGTTTATCTTTGAAAAC
GGTGACGTCTACGTTCTCAACCTGGAGGATTATCACTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8602.65 Da        Isoelectric Point: 4.5203

>AT194210 WP_076565118.1 NZ_CP070503:5716949-5717179 [Pseudomonas atacamensis]
MEQTTIFMSNRSQAVRLPKAVAMPADVKRVEVIAIGRTRVITPAGESWDSWFDGDSVSPDFMANREQPTEQERESF

Download         Length: 231 bp

>AT194210 NZ_CP093390:c2120848-2120564 [Salmonella enterica]
ATGGCTATGTTCGATCCTGCTTACCCTGGCGAAATCATTGCCGAAATTCTGGAAGACCAGGGCGTAAGCCTGCGTCAGTT
TGCTGTAGCTATGAATATTGCGCCATCAACCGCCAGCCGTATTCTGAGCGGTAAAGTAAGTATCACGCCAGAAATGGCGG
TTAAGCTGGCTATCGTTCTTGGCGGCGATGCCGAAAGCTGGCTTAACCTTCAGAATAACTACAGTCTGTCGCAGGCACGT
AAAACAGTGGATATAACTCATGTTCACCGTCTGTCTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References