Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 203455..205079 Replicon chromosome
Accession NZ_CP070503
Organism Pseudomonas atacamensis strain SM1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JWU58_RS00940 Protein ID WP_206421352.1
Coordinates 203455..204804 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JWU58_RS00945 Protein ID WP_039757273.1
Coordinates 204801..205079 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWU58_RS00930 198833..200641 + 1809 WP_122506268.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -
JWU58_RS00935 200849..202690 - 1842 WP_123441971.1 autotransporter outer membrane beta-barrel domain-containing protein -
JWU58_RS00940 203455..204804 + 1350 WP_206421352.1 HipA domain-containing protein Toxin
JWU58_RS00945 204801..205079 + 279 WP_039757273.1 helix-turn-helix domain-containing protein Antitoxin
JWU58_RS00950 205087..205923 - 837 WP_041476583.1 amino acid ABC transporter permease -
JWU58_RS00955 205920..206738 - 819 WP_206421353.1 transporter substrate-binding domain-containing protein -
JWU58_RS00960 206852..207754 + 903 WP_206421354.1 homocysteine S-methyltransferase family protein -
JWU58_RS00965 207875..208546 - 672 WP_206421355.1 GNAT family N-acetyltransferase -
JWU58_RS00970 208559..209005 - 447 WP_123441876.1 GNAT family N-acetyltransferase -
JWU58_RS00975 209016..209639 - 624 WP_073471070.1 FMN-binding negative transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49941.56 Da        Isoelectric Point: 5.1618

>T194203 WP_206421352.1 NZ_CP070503:203455-204804 [Pseudomonas atacamensis]
MYNLTLQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLEVIRMLAGLWRKAGQASQIAGLVTDYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPRELERAGDVDWRGVCRVLADSVDPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGFPARTMNHPSVHLKKLEQRLKEWDLQ

Download         Length: 1350 bp

>T194203 NZ_CP093387:c91147-90842 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10316.12 Da        Isoelectric Point: 10.7364

>AT194203 WP_039757273.1 NZ_CP070503:204801-205079 [Pseudomonas atacamensis]
MSLTVLERTALIESIQQALAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTI

Download         Length: 279 bp

>AT194203 NZ_CP093387:c91367-91149 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References