Detailed information of TA system TA194198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 5569187..5569884
• Replicon: chromosome
• Accession: NZ_CP070499
• Organism: Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JQS43_RS25330
• Protein ID: WP_239676871.1
• Coordinates: 5569187..5569633 (-)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQS43_RS25335
• Protein ID: WP_239676872.1
• Coordinates: 5569630..5569884 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQS43_RS25295 (JQS43_25195)	5564278..5564574	+	297	WP_239676865.1	UBP-type zinc finger domain-containing protein	-
JQS43_RS25300 (JQS43_25200)	5564601..5565191	-	591	WP_239676866.1	hypothetical protein	-
JQS43_RS25305 (JQS43_25205)	5565506..5566246	+	741	WP_239676867.1	thioredoxin domain-containing protein	-
JQS43_RS25310 (JQS43_25210)	5566258..5566914	+	657	WP_239676868.1	vitamin K epoxide reductase family protein	-
JQS43_RS25315 (JQS43_25215)	5566964..5568163	-	1200	WP_239676869.1	RtcB family protein	-
JQS43_RS25325 (JQS43_25225)	5568668..5568952	+	285	WP_239676870.1	antibiotic biosynthesis monooxygenase	-
JQS43_RS25330 (JQS43_25230)	5569187..5569633	-	447	WP_239676871.1	hypothetical protein	Toxin
JQS43_RS25335 (JQS43_25235)	5569630..5569884	-	255	WP_239676872.1	hypothetical protein	Antitoxin
JQS43_RS25340 (JQS43_25240)	5570353..5571111	+	759	WP_239676873.1	HAD family hydrolase	-
JQS43_RS25345 (JQS43_25245)	5571230..5571547	-	318	WP_239676874.1	type II toxin-antitoxin system PemK/MazF family toxin	-
JQS43_RS25350 (JQS43_25250)	5571537..5571776	-	240	WP_239676875.1	hypothetical protein	-
JQS43_RS25355 (JQS43_25255)	5572431..5572649	-	219	WP_239676876.1	type II toxin-antitoxin system HicB family antitoxin	-
JQS43_RS25360 (JQS43_25260)	5572931..5573524	+	594	WP_239676877.1	nucleotidyltransferase domain-containing protein	-
JQS43_RS25365 (JQS43_25265)	5573521..5573943	+	423	WP_239676878.1	hypothetical protein	-
JQS43_RS25370 (JQS43_25270)	5574206..5574853	+	648	WP_239676879.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-135)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 16390.60 Da
• Isoelectric Point: 6.6402

>T194198 WP_239676871.1 NZ_CP070499:c5569633-5569187 [Natronosporangium hydrolyticum]
VSLLADVGVWLAAVWGRHVHHPVAASWFEQQPGGVILCRVTQMSLLRLLSNPAVMGADATSRRDAWAVVDRLRADDRVSW
ADEPLQLEHVWRAISARDDGSHKLWTDDYLAAFAQAADLSLVTLDRQLARRYPSVRVETLGPSLTAAN

Nucleotide

• Length: 447 bp

>T194198 NZ_CP093386:c4210449-4210165 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8735.04 Da
• Isoelectric Point: 5.6423

>AT194198 WP_239676872.1 NZ_CP070499:c5569884-5569630 [Natronosporangium hydrolyticum]
MRTTIDLPAEVMQAAKIRAAELGVTLKELFSRAITHELGLPAARQGASRVTLPLVGVAATPAVHVTNADIEAALAADEAE
RYGG

Nucleotide

• Length: 255 bp

>AT194198 NZ_CP093386:c4210681-4210439 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA