Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4605937..4606521 Replicon chromosome
Accession NZ_CP070499
Organism Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag JQS43_RS20700 Protein ID WP_239676039.1
Coordinates 4605937..4606224 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag JQS43_RS20705 Protein ID WP_239676040.1
Coordinates 4606234..4606521 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQS43_RS20690 (JQS43_20615) 4601287..4603626 - 2340 WP_239676037.1 hypothetical protein -
JQS43_RS20695 (JQS43_20620) 4603725..4605770 - 2046 WP_239676038.1 thioredoxin domain-containing protein -
JQS43_RS20700 (JQS43_20625) 4605937..4606224 + 288 WP_239676039.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JQS43_RS20705 (JQS43_20630) 4606234..4606521 + 288 WP_239676040.1 HigA family addiction module antitoxin Antitoxin
JQS43_RS20710 (JQS43_20635) 4606610..4607614 - 1005 WP_239676041.1 phosphotransferase -
JQS43_RS20715 (JQS43_20640) 4607960..4609252 - 1293 WP_239676042.1 hypothetical protein -
JQS43_RS20720 (JQS43_20645) 4609334..4610026 + 693 WP_239676043.1 DUF429 domain-containing protein -
JQS43_RS20725 (JQS43_20650) 4610192..4610530 + 339 WP_239676044.1 helix-turn-helix transcriptional regulator -
JQS43_RS20730 (JQS43_20655) 4610548..4611414 + 867 WP_239676045.1 ImmA/IrrE family metallo-endopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10746.16 Da        Isoelectric Point: 10.7483

>T194196 WP_239676039.1 NZ_CP070499:4605937-4606224 [Natronosporangium hydrolyticum]
MIASFGDAATEALFHGRTSRARRIPANIRAAALRKLDMVNAARELRDLRVPPGNRLEALKGDRAGDHSIRVNDQWRIVFR
WESGDAHEVTIVDYH

Download         Length: 288 bp

>T194196 NZ_CP093386:3705106-3705381 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCTAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10268.86 Da        Isoelectric Point: 7.3203

>AT194196 WP_239676040.1 NZ_CP070499:4606234-4606521 [Natronosporangium hydrolyticum]
MLPANRIPTHPGEVLSEEFLKPLGLTQVALAEHLGVPVQRINELVRGKRGVTPETAWLLAGAFGTTPDFWINLQTAHDLA
VTRPTRGVPQLAQAA

Download         Length: 288 bp

>AT194196 NZ_CP093386:c3705371-3704949 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTAGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References