Detailed information of TA system TA194190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 1719592..1720286
• Replicon: chromosome
• Accession: NZ_CP070499
• Organism: Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JQS43_RS07745
• Protein ID: WP_239678378.1
• Coordinates: 1719592..1719993 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQS43_RS07750
• Protein ID: WP_239678379.1
• Coordinates: 1719990..1720286 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQS43_RS07715 (JQS43_07675)	1715008..1716048	+	1041	WP_239678372.1	uroporphyrinogen decarboxylase	-
JQS43_RS07720 (JQS43_07680)	1716045..1717436	+	1392	WP_239678373.1	protoporphyrinogen oxidase	-
JQS43_RS07725 (JQS43_07685)	1717433..1718155	+	723	WP_239678374.1	chlorite dismutase family protein	-
JQS43_RS07730 (JQS43_07690)	1718181..1718639	-	459	WP_239678375.1	GNAT family N-acetyltransferase	-
JQS43_RS07735 (JQS43_07695)	1718660..1718917	-	258	WP_239678376.1	Prokaryotic metallothionein	-
JQS43_RS07740 (JQS43_07700)	1719082..1719465	-	384	WP_239678377.1	peptide-methionine (R)-S-oxide reductase MsrB	-
JQS43_RS07745 (JQS43_07705)	1719592..1719993	-	402	WP_239678378.1	type II toxin-antitoxin system VapC family toxin	Toxin
JQS43_RS07750 (JQS43_07710)	1719990..1720286	-	297	WP_239678379.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JQS43_RS07755 (JQS43_07715)	1720420..1721586	-	1167	WP_239678380.1	ROK family transcriptional regulator	-
JQS43_RS07760 (JQS43_07720)	1721637..1721795	+	159	WP_239678381.1	hypothetical protein	-
JQS43_RS07765 (JQS43_07725)	1721957..1723072	+	1116	WP_239678382.1	hypothetical protein	-
JQS43_RS07770 (JQS43_07730)	1723088..1723828	+	741	WP_239678383.1	SDR family oxidoreductase	-
JQS43_RS07775 (JQS43_07735)	1723933..1724985	+	1053	WP_239678384.1	non-homologous end-joining DNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14384.15 Da
• Isoelectric Point: 4.1774

>T194190 WP_239678378.1 NZ_CP070499:c1719993-1719592 [Natronosporangium hydrolyticum]
VSVYYLDTSAALKLLAEESHSRAFATFYDDHANASWVSSALLQIEVIRAVTRVMPAVLPDARDLLSAFDYVAIDDEIVDA
AMSEPDRGLRSLDAIHLATARALDPDLTGVVTYGDRLARAAQDAGMTVFAPQD

Nucleotide

• Length: 402 bp

>T194190 NZ_CP093386:839523-839936 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11061.59 Da
• Isoelectric Point: 10.8006

>AT194190 WP_239678379.1 NZ_CP070499:c1720286-1719990 [Natronosporangium hydrolyticum]
MPTTSDHSVGLRELRHHTSEVLARVRHGETIDVTEYGRLVARIVPVEQREPAPVLDRMISAGRVRLATRPGYRPRMRPAS
GADRLGDALADLRAEERW

Nucleotide

• Length: 297 bp

>AT194190 NZ_CP093386:839276-839542 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA