Detailed information of TA system TA194189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1646145..1646806
• Replicon: chromosome
• Accession: NZ_CP070499
• Organism: Natronosporangium hydrolyticum strain DSM 106523

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JQS43_RS07355
• Protein ID: WP_239678306.1
• Coordinates: 1646375..1646806 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JQS43_RS07350
• Protein ID: WP_239678305.1
• Coordinates: 1646145..1646375 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQS43_RS07330 (JQS43_07280)	1641812..1642540	+	729	WP_239678301.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
JQS43_RS07335 (JQS43_07285)	1642738..1644186	+	1449	WP_239678302.1	N-acetylglucosamine/diacetylchitobiose ABC transporter substrate-binding protein	-
JQS43_RS07340 (JQS43_07290)	1644240..1645175	+	936	WP_239678303.1	sugar ABC transporter permease	-
JQS43_RS07345 (JQS43_07295)	1645175..1646092	+	918	WP_239678304.1	carbohydrate ABC transporter permease	-
JQS43_RS07350 (JQS43_07300)	1646145..1646375	+	231	WP_239678305.1	ribbon-helix-helix protein, CopG family	Antitoxin
JQS43_RS07355 (JQS43_07305)	1646375..1646806	+	432	WP_239678306.1	PIN domain-containing protein	Toxin
JQS43_RS07360 (JQS43_07310)	1646796..1647149	-	354	WP_239678307.1	histidine triad nucleotide-binding protein	-
JQS43_RS07365 (JQS43_07315)	1647306..1648364	+	1059	WP_239678308.1	PhoH family protein	-
JQS43_RS07370 (JQS43_07320)	1648421..1648885	+	465	WP_239678309.1	rRNA maturation RNase YbeY	-
JQS43_RS07375 (JQS43_07325)	1648901..1650271	+	1371	WP_239678310.1	hemolysin family protein	-
JQS43_RS07380 (JQS43_07330)	1650264..1650623	+	360	WP_239678311.1	cytidine deaminase	-
JQS43_RS07385 (JQS43_07335)	1650616..1651536	+	921	WP_239678312.1	GTPase Era	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-133)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.15 Da
• Isoelectric Point: 6.9106

>T194189 WP_239678306.1 NZ_CP070499:1646375-1646806 [Natronosporangium hydrolyticum]
MLVDANLLLYAVDTRSPFHDRAREWLTGALNGRERVGLPWQCLTAFVRIATHPRAAQRPLTPAQAWEHVSSWLACEVAWT
PLPTNHHAEVLGALVVEHDLRGNLVSDAHLAALAIEHGLKLYSADSDFARFPKLTWVNPLVSG

Nucleotide

• Length: 432 bp

>T194189 NZ_CP093386:365294-365569 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8340.25 Da
• Isoelectric Point: 4.7027

>AT194189 WP_239678305.1 NZ_CP070499:1646145-1646375 [Natronosporangium hydrolyticum]
MRTTITFDDDTAAAVDQLRRSGARGVSQIVNDLIRAGLRHREERPPFVQSTSDLGIQVDVANVAEALDLLDGPDHR

Nucleotide

• Length: 231 bp

>AT194189 NZ_CP093386:365031-365291 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA