Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2752351..2752999 Replicon chromosome
Accession NZ_CP070338
Organism Mycobacterium tuberculosis strain 11502

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JR349_RS12725 Protein ID WP_003899414.1
Coordinates 2752351..2752674 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JR349_RS12730 Protein ID WP_003899415.1
Coordinates 2752754..2752999 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR349_RS12695 2747674..2748672 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JR349_RS12700 2748686..2749150 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JR349_RS12705 2749138..2749389 + 252 WP_003908028.1 hypothetical protein -
JR349_RS12710 2749560..2750999 - 1440 WP_003901443.1 phage major capsid protein -
JR349_RS12715 2751007..2751540 - 534 WP_003899412.1 HK97 family phage prohead protease -
JR349_RS12720 2751693..2752184 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JR349_RS12725 2752351..2752674 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JR349_RS12730 2752754..2752999 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JR349_RS12735 2752996..2754423 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
JR349_RS12740 2754425..2754817 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JR349_RS12745 2754814..2755074 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JR349_RS12750 2755091..2755453 - 363 WP_003900543.1 hypothetical protein -
JR349_RS12755 2755456..2756583 - 1128 WP_003899420.1 site-specific integrase -
JR349_RS12760 2756728..2756955 - 228 WP_003899421.1 hypothetical protein -
JR349_RS12765 2756952..2757341 - 390 WP_003899422.1 hypothetical protein -
JR349_RS12770 2757247..2757519 + 273 WP_003900544.1 hypothetical protein -
JR349_RS12775 2757618..2757851 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2747674..2759670 11996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T193875 WP_003899414.1 NZ_CP070338:c2752674-2752351 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T193875 NZ_CP093249:2733315-2733569 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT193875 WP_003899415.1 NZ_CP070338:c2752999-2752754 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT193875 NZ_CP093249:2733067-2733318 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCTGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References