Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4004437..4004695 Replicon chromosome
Accession NZ_CP070292
Organism Escherichia albertii strain Sample 166

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JRC43_RS19575 Protein ID WP_000809168.1
Coordinates 4004543..4004695 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4004437..4004494 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JRC43_RS19560 4000244..4001491 - 1248 WP_025237694.1 hypothetical protein -
JRC43_RS19565 4001645..4003138 - 1494 WP_025237695.1 sulfatase-like hydrolase/transferase -
JRC43_RS19570 4003159..4003920 - 762 WP_001276206.1 outer membrane protein OmpK -
- 4004437..4004494 - 58 - - Antitoxin
JRC43_RS19575 4004543..4004695 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JRC43_RS19580 4004804..4005934 - 1131 WP_001118445.1 molecular chaperone DnaJ -
JRC43_RS19585 4006023..4007939 - 1917 WP_000516135.1 molecular chaperone DnaK -
JRC43_RS19590 4008314..4008718 + 405 WP_000833521.1 DUF2541 family protein -
JRC43_RS19595 4008745..4009458 + 714 WP_001102345.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T193750 WP_000809168.1 NZ_CP070292:4004543-4004695 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T193750 NZ_CP093202:1991345-1991533 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 58 bp

>AT193750 NZ_CP070292:c4004494-4004437 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References