Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1639553..1640163 Replicon chromosome
Accession NZ_CP070273
Organism Marinomonas foliarum strain JZW

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JSY38_RS07615 Protein ID WP_205116718.1
Coordinates 1639981..1640163 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JSY38_RS07610 Protein ID WP_205116255.1
Coordinates 1639553..1639957 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSY38_RS07585 1635026..1635538 - 513 WP_114411552.1 transcriptional regulator NrdR -
JSY38_RS07590 1635699..1636604 + 906 WP_205116250.1 EamA family transporter -
JSY38_RS07595 1636860..1638521 + 1662 WP_114411550.1 energy-dependent translational throttle protein EttA -
JSY38_RS07600 1638593..1639147 - 555 WP_205116252.1 hypothetical protein -
JSY38_RS07605 1639219..1639520 - 302 Protein_1458 DNA-binding transcriptional regulator -
JSY38_RS07610 1639553..1639957 - 405 WP_205116255.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JSY38_RS07615 1639981..1640163 - 183 WP_205116718.1 type II toxin-antitoxin system HicA family toxin Toxin
JSY38_RS07620 1640373..1641329 - 957 WP_205116258.1 EamA family transporter -
JSY38_RS07625 1641466..1641927 + 462 WP_205116260.1 winged helix-turn-helix transcriptional regulator -
JSY38_RS07630 1642005..1643618 - 1614 WP_205116262.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6948.13 Da        Isoelectric Point: 10.5957

>T193598 WP_205116718.1 NZ_CP070273:c1640163-1639981 [Marinomonas foliarum]
MKSREVIQMLVEDGWYEVRVKGSHVQFKHPNKKGTVTVPHPKKDLPIGTFNSIKKQAQLY

Download         Length: 183 bp

>T193598 NZ_CP093035:c1771499-1771212 [Bartonella krasnovii]
ATGCTTCCGGTTGTTTGGTTGTCTTCGGCTCGCGATGATTTGCGTCAGATTTTAACTTACATTGCTCGCGAAAATCCATC
CGCTGCACGCCGAATGAAAAGGTTTTTGGAAACATCTGTACTGCCATTGGCTGAACATCCATATCTGTACAGACAGAGTG
AGAGGATATTAGGGTTACGGGAAATTATAGCACATCCAAATTACCTTATATTGTATCGAGTAGCTGCAAATCAGATCGAA
ATTGTAGCTGTCGTACATGCCCGACGTGAATTCCCTACCTCTCTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14522.60 Da        Isoelectric Point: 4.4818

>AT193598 WP_205116255.1 NZ_CP070273:c1639957-1639553 [Marinomonas foliarum]
MKYPIVLHTDNGVSYGVTVPDVPGCFSAGDTFDEALEMAEEAIFSHLELLLEDGEDILTASPIATHKDNPDYADGVWAVV
NVDITPLLGKSEKINVTLPHLLITKIDKIVAANPKYKSRSGFLAEASKKVLQLT

Download         Length: 405 bp

>AT193598 NZ_CP093035:c1771687-1771499 [Bartonella krasnovii]
ATGAAAAACACCCTTTCTCCGTTCATTTCAGAGTTCGAAACCGTTGAACAGGAAAGCAGCCACACGGCGTGGTTGCGCGA
TAAGGTCGCGATAAGTCTTGCAAACCTATCTCCTCCTATTCCGCATGATGAGGTCATGGCTGAAATGGACGTTATAATCA
GTCAGCTTGAAAATGAACAGAAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References