Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3440744..3441266 Replicon chromosome
Accession NZ_CP070134
Organism Escherichia coli strain FDAARGOS_1281

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag I6K11_RS17490 Protein ID WP_001105433.1
Coordinates 3440976..3441266 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6K11_RS17485 Protein ID WP_000212715.1
Coordinates 3440744..3440986 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K11_RS17465 (3436460) 3436460..3437833 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
I6K11_RS17470 (3437985) 3437985..3438536 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
I6K11_RS17475 (3438630) 3438630..3439982 + 1353 WP_001162173.1 metalloprotease PmbA -
I6K11_RS17480 (3440166) 3440166..3440552 + 387 WP_001232246.1 cytochrome b562 -
I6K11_RS17485 (3440744) 3440744..3440986 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K11_RS17490 (3440976) 3440976..3441266 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K11_RS17495 (3441267) 3441267..3441731 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K11_RS17500 (3441916) 3441916..3444054 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
I6K11_RS17505 (3444448) 3444448..3446103 - 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T193284 WP_001105433.1 NZ_CP070134:3440976-3441266 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T193284 NZ_CP092830:c2499257-2499006 [Pseudomonas azotoformans]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAACGAGCACACGGCATTTACCTGGCCCGAACTCGTGACACTGCT
GCGCCGGCTGGGCTACACACAGATTGAAGGGGCTGGAAGCCGCGTCAAATTCGACATCGGTGACCCCAGTGCAATGATTA
CCTTGCACAAGCCTCACCCGGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAGCAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT193284 WP_000212715.1 NZ_CP070134:3440744-3440986 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT193284 NZ_CP092830:c2499009-2498644 [Pseudomonas azotoformans]
GTGAACAATCAACTGCAACACAAAGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
TCTGTTCATCAAGGCGCTGGTGAGCTACGAAGGAAAAACCGTCGCCGAGCTGGACGGCGCGTTCCGGGAGGCGGTGGACG
ACTACCTCGCCACCTGCCAGGCCCTGGGGCAAACACCGGAAAAACCCTGCAAGGGTTCATTCAACGTACGCGTCGGCCAT
GACTTGCACTTGGCGGCAGCCCTGGCGGCGACCCGCAAAAAAGTGACCCTCAATGACCTGACACGCCAGGCCTTGAATGA
GTTTTTACAACATCATGGCAACGACCCGTGCCCTGCGGTTAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References