Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3272..4008 Replicon plasmid unnamed3
Accession NZ_CP070108
Organism Klebsiella pneumoniae strain FDAARGOS_1314

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag I6K44_RS26845 Protein ID WP_003026803.1
Coordinates 3526..4008 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag I6K44_RS26840 Protein ID WP_003026799.1
Coordinates 3272..3538 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K44_RS26805 463..726 + 264 WP_009310051.1 hypothetical protein -
I6K44_RS26810 723..1289 + 567 WP_009310052.1 hypothetical protein -
I6K44_RS26815 1320..1814 + 495 WP_009310053.1 hypothetical protein -
I6K44_RS26820 1858..2226 + 369 WP_009310054.1 hypothetical protein -
I6K44_RS26825 2257..2460 + 204 WP_004098931.1 hemolysin expression modulator Hha -
I6K44_RS26830 2509..2766 + 258 WP_004098928.1 hypothetical protein -
I6K44_RS26835 2842..3096 + 255 WP_004118702.1 hypothetical protein -
I6K44_RS26840 3272..3538 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
I6K44_RS26845 3526..4008 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
I6K44_RS26850 4210..5613 + 1404 WP_103214967.1 ISNCY-like element ISKpn21 family transposase -
I6K44_RS26855 5642..6274 - 633 WP_001567369.1 hypothetical protein -
I6K44_RS26860 6501..7847 + 1347 WP_077250283.1 ISNCY family transposase -
I6K44_RS26865 7906..8502 + 597 Protein_13 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..173599 173599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T193156 WP_003026803.1 NZ_CP070108:3526-4008 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T193156 NZ_CP092739:c2888177-2887836 [Leptospira interrogans]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTTTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT193156 WP_003026799.1 NZ_CP070108:3272-3538 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT193156 NZ_CP092739:c2888412-2888164 [Leptospira interrogans]
ATGAAGACGGCGATTTCAATTCCTGATGAGTTATTTAGGGCTGCCGAGAAAATAGCTAAAAAACTTGGGATTCCTCGAAG
CCAGTTATTTGCAAAAGCATTAGAAGAATTTATCCAATCTCATAGTAAAGAATCTGTAACTGAGAAATTAAATAAAATCT
ACAGTAATAAATCCAAAGAAACTAGAAATAATATTACTGACTTATCCGTAGAATCGCTTCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References