Detailed information of TA system TA193155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4702713..4704301
• Replicon: chromosome
• Accession: NZ_CP070105
• Organism: Klebsiella pneumoniae strain FDAARGOS_1314

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6K44_RS23055
• Protein ID: WP_032436337.1
• Coordinates: 4702979..4704301 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: I6K44_RS23050
• Protein ID: WP_002904790.1
• Coordinates: 4702713..4702979 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K44_RS23025	4697742..4698665	+	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-
I6K44_RS23030	4698646..4699800	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
I6K44_RS23035	4700146..4701525	+	1380	WP_032412205.1	purine permease	-
I6K44_RS23040	4701503..4702003	+	501	WP_032436335.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6K44_RS23045	4702000..4702326	+	327	WP_032436336.1	hydroxyisourate hydrolase	-
I6K44_RS23050	4702713..4702979	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K44_RS23055	4702979..4704301	+	1323	WP_032436337.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K44_RS23060	4704318..4705610	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
I6K44_RS23065	4705751..4706755	-	1005	WP_032436338.1	type 1 fimbrial protein	-
I6K44_RS23070	4706743..4709244	-	2502	WP_032436339.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49106.39 Da
• Isoelectric Point: 7.5617

>T193155 WP_032436337.1 NZ_CP070105:4702979-4704301 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T193155 NZ_CP092738:62857-63180 [Leptospira interrogans]
ATGGTGATTTCTCAATACGAAGTATATCTAATAAATTTAGATCCAACGGTTGGACATGAGATAAAAAAATCAAGACCTTG
TGCAATAATCTCACCCAATGAAATGAATAAAACGATTGGAACAATTATTATTGCACCAATGACTACAAAATCTCGATCAT
ATCCGACAAGAGTTGAATTAACCTTTCAAGGAAAGAAGGGTTGGATTGTGTTAGATCAGATTCGAGCTGTTGATAAAACA
CGTCTGGTAAAGAAGTTAGGAAAAATAGATCCCAAAACAGTTAATAAAATGAAACTGGTAATAAAGGAAATGTTGGTTGA
TTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT193155 WP_002904790.1 NZ_CP070105:4702713-4702979 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT193155 NZ_CP092738:62615-62863 [Leptospira interrogans]
ATGAAGGCTTCAGTCGTAAAAATAGGCAATTCCAAAGGTATTCGAATTCCCAAGGCAGTCTTAGAAGAATGTCATATTGA
AGAAGAAGTAGATTTACTAATCGATAATAACAAATTAATTATTGTACCTCTAAAATCGAAACCAAGAGAAGGGTGGGAAA
AACAATTTAAAACAATGTCATCTAATAAAGATGATAAATTATTTATTCCTGATTCAATAGATTTATTAGACAAGGATTGG
GAATGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8