Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1481160..1481682 Replicon chromosome
Accession NZ_CP070077
Organism Escherichia coli strain FDAARGOS_1371

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag I6L01_RS06950 Protein ID WP_001105433.1
Coordinates 1481160..1481450 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6L01_RS06955 Protein ID WP_000212715.1
Coordinates 1481440..1481682 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L01_RS06935 (1476323) 1476323..1477978 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
I6L01_RS06940 (1478372) 1478372..1480510 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
I6L01_RS06945 (1480695) 1480695..1481159 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6L01_RS06950 (1481160) 1481160..1481450 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L01_RS06955 (1481440) 1481440..1481682 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6L01_RS06960 (1481874) 1481874..1482260 - 387 WP_001232246.1 cytochrome b562 -
I6L01_RS06965 (1482444) 1482444..1483796 - 1353 WP_001162173.1 metalloprotease PmbA -
I6L01_RS06970 (1483890) 1483890..1484441 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
I6L01_RS06975 (1484593) 1484593..1485966 - 1374 WP_033550800.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T192983 WP_001105433.1 NZ_CP070077:c1481450-1481160 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T192983 NZ_CP092639:697526-697822 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT192983 WP_000212715.1 NZ_CP070077:c1481682-1481440 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT192983 NZ_CP092639:697824-698219 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References