Detailed information of TA system TA192854

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4524421..4524679
• Replicon: chromosome
• Accession: NZ_CP070048
• Organism: Escherichia coli strain FDAARGOS_1290

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6K20_RS21845
• Protein ID: WP_000809168.1
• Coordinates: 4524421..4524573 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4524622..4524679 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K20_RS21825	4519663..4520376	-	714	WP_204693193.1	acidic protein MsyB	-
I6K20_RS21830	4520402..4520806	-	405	WP_000843584.1	DUF2541 family protein	-
I6K20_RS21835	4521182..4523098	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6K20_RS21840	4523187..4524317	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6K20_RS21845	4524421..4524573	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	4524622..4524679	+	58	-	-	Antitoxin
I6K20_RS21850	4525159..4526325	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
I6K20_RS21855	4526391..4527290	+	900	WP_001300855.1	transcriptional activator NhaR	-
I6K20_RS21860	4527328..4528287	-	960	WP_000871674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T192854 WP_000809168.1 NZ_CP070048:c4524573-4524421 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T192854 NZ_CP092563:c2442894-2442628 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT192854 NZ_CP070048:4524622-4524679 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin