Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1805067..1805865 Replicon chromosome
Accession NZ_CP069978
Organism Escherichia coli strain FDAARGOS_1299

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag I6K29_RS08875 Protein ID WP_001094434.1
Coordinates 1805067..1805441 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6K29_RS08880 Protein ID WP_001552747.1
Coordinates 1805488..1805865 (-) Length 126 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K29_RS08840 (1800656) 1800656..1801210 - 555 WP_001001909.1 molecular chaperone YcdY -
I6K29_RS08845 (1801234) 1801234..1801971 - 738 WP_000283664.1 zinc-binding phosphatase -
I6K29_RS08850 (1802026) 1802026..1802964 - 939 WP_000351298.1 glyoxylate/hydroxypyruvate reductase GhrA -
I6K29_RS08860 (1803435) 1803435..1804277 - 843 WP_001280460.1 DUF4942 domain-containing protein -
I6K29_RS08865 (1804370) 1804370..1804567 - 198 WP_000839257.1 DUF957 domain-containing protein -
I6K29_RS08870 (1804579) 1804579..1805070 - 492 WP_000976859.1 DUF5983 family protein -
I6K29_RS08875 (1805067) 1805067..1805441 - 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
I6K29_RS08880 (1805488) 1805488..1805865 - 378 WP_001552747.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K29_RS08885 (1805915) 1805915..1806559 - 645 WP_000086759.1 hypothetical protein -
I6K29_RS08890 (1806578) 1806578..1806799 - 222 WP_000692315.1 DUF987 domain-containing protein -
I6K29_RS08895 (1806862) 1806862..1807338 - 477 WP_001186727.1 RadC family protein -
I6K29_RS08900 (1807354) 1807354..1807827 - 474 WP_001542276.1 antirestriction protein -
I6K29_RS08905 (1807921) 1807921..1808166 - 246 WP_001164966.1 hypothetical protein -
I6K29_RS08910 (1808166) 1808166..1808987 - 822 WP_001234585.1 DUF932 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T192443 WP_001094434.1 NZ_CP069978:c1805441-1805067 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T192443 NZ_CP092400:56280-56762 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13757.63 Da        Isoelectric Point: 6.3127

>AT192443 WP_001552747.1 NZ_CP069978:c1805865-1805488 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT192443 NZ_CP092400:56026-56292 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q1RDD2


Antitoxin

Source ID Structure

References