Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1668709..1669544 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag I6K10_RS08820 Protein ID WP_029701676.1
Coordinates 1668709..1669086 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag I6K10_RS08825 Protein ID WP_021553056.1
Coordinates 1669176..1669544 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS08800 (1665076) 1665076..1666614 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
I6K10_RS08805 (1667363) 1667363..1668205 - 843 WP_022645115.1 DUF4942 domain-containing protein -
I6K10_RS08810 (1668290) 1668290..1668484 - 195 WP_024181941.1 DUF957 domain-containing protein -
I6K10_RS08815 (1668563) 1668563..1668712 - 150 Protein_1531 DUF5983 family protein -
I6K10_RS08820 (1668709) 1668709..1669086 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
I6K10_RS08825 (1669176) 1669176..1669544 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K10_RS08830 (1669707) 1669707..1669928 - 222 WP_000692345.1 DUF987 domain-containing protein -
I6K10_RS08835 (1669993) 1669993..1670469 - 477 WP_021553055.1 RadC family protein -
I6K10_RS08840 (1670485) 1670485..1670964 - 480 WP_001564060.1 antirestriction protein -
I6K10_RS08845 (1671230) 1671230..1672048 - 819 WP_001175165.1 DUF932 domain-containing protein -
I6K10_RS08850 (1672138) 1672138..1672371 - 234 WP_001278293.1 DUF905 family protein -
I6K10_RS08855 (1672377) 1672377..1673054 - 678 WP_001097302.1 hypothetical protein -
I6K10_RS08860 (1673202) 1673202..1673882 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1657588..1703329 45741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T192396 WP_029701676.1 NZ_CP069973:c1669086-1668709 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T192396 NZ_CP092371:c17160-16597 [Flavobacterium sp. CBA20B-1]
ATGATTCATAGTGTTCGATACAAAGCAGTTCTTGATACCAATGTAATATTTCCTATCGTGATTAGAGATTTATTATTTTG
GTTTGCTCATTATGATTTATATACCCCAAAATGGAGTAAAATCATTTTTGATGAATGGAAATCTGTAATGATTCGAAAGG
GAGTAGAATCTTCACAAGCAGAGAAGCGGATAAACATAGCAAATTTGGCATTTCCCGATGCTTTAGTATTAAATTATGAA
GGTTTAATTGATACTTTAAGTTTACCTGATAAAGATGATAGACATGTATTAGCAGCTGCTATTAAAGTCAATGCCAATAT
TATTGTAACTAATAACTTGAAAGATTTTCCAGATGATTATTTAGACTCTTTTGGATTGAAGGCAGTTTGTGCGGATGATT
TTCTTACGGATATCATTGATTTAAATCCAAAAATAGCCCTTCAAGCTTTTAAAGATTTGGTATTAAATCGCAAAAACCCG
GCAATGGATGAATTTCAAGTATTAGAAAGTTTTAGAAAAAATGGATTAAATCAAACAGCAGATTATTTACATGCTTTATT
GTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT192396 WP_021553056.1 NZ_CP069973:c1669544-1669176 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT192396 NZ_CP092371:c17605-17150 [Flavobacterium sp. CBA20B-1]
ATGGAAGCATTAGATTATATAAAAAGACCCACTAAGAAAGAACAACGAGTGGCTATTGAATCTTATTCAGCACTTTCTTC
AATTTTATCACAATTGAAGAAAGATGATACTGAAATAGAAATCGAAGAAACAAACGACAGAATTAAAATACCTTTTAAAG
CTTTAAAACTTTTAAGTGAAATTTTAAAGTCAATGAGTGAAGGAAATCCAATTTCTATTGTACCTATTGCAACGGAAGTC
ACTACTCAAAAAGCAGCTGAAATATTGGGTTGTTCAAGGCCTCATTTAGTTAAACTTTTAGAACAAGGCGAAATTGATTT
TACAATGGTTGGAAGACATCGTCGTATTTTATTTGAAGATGTAATCAAATATAAAAACGAAATGAAGCAAAAACAGAAAA
AGCATATCATTGATATTATGAACTTTGATGATGAAATAGGTTTATATGATTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References