Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 3811439..3812139 Replicon chromosome
Accession NZ_CP069945
Organism Escherichia coli strain FDAARGOS_1373

Toxin (Protein)


Gene name ypjF Uniprot ID A0A7H4NX47
Locus tag I6L03_RS18010 Protein ID WP_001546951.1
Coordinates 3811439..3811762 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6L03_RS18015 Protein ID WP_204628137.1
Coordinates 3811783..3812139 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L03_RS17995 (3807127) 3807127..3807963 - 837 WP_000383248.1 5-dehydro-4-deoxy-D-glucuronate isomerase -
I6L03_RS18000 (3808250) 3808250..3809431 - 1182 WP_000656017.1 acetyl-CoA C-acetyltransferase -
I6L03_RS18005 (3809686) 3809686..3810915 + 1230 WP_000065950.1 amino acid permease -
I6L03_RS18010 (3811439) 3811439..3811762 - 324 WP_001546951.1 TA system toxin CbtA family protein Toxin
I6L03_RS18015 (3811783) 3811783..3812139 - 357 WP_204628137.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L03_RS18020 (3812165) 3812165..3812386 - 222 WP_012543032.1 DUF987 domain-containing protein -
I6L03_RS18025 (3812383) 3812383..3812925 - 543 WP_204628138.1 DNA repair protein RadC -
I6L03_RS18030 (3812938) 3812938..3813381 - 444 WP_204628139.1 antirestriction protein -
I6L03_RS18035 (3813412) 3813412..3814233 - 822 WP_012543035.1 DUF932 domain-containing protein -
I6L03_RS18040 (3814353) 3814353..3814826 - 474 WP_204628140.1 hypothetical protein -
I6L03_RS18045 (3814898) 3814898..3815350 - 453 WP_204628141.1 hypothetical protein -
I6L03_RS18050 (3815386) 3815386..3816102 - 717 WP_012543038.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12496.55 Da        Isoelectric Point: 7.1331

>T192244 WP_001546951.1 NZ_CP069945:c3811762-3811439 [Escherichia coli]
MKFLPTTNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLMNRN

Download         Length: 324 bp

>T192244 NZ_CP092252:2762163-2762270 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13175.89 Da        Isoelectric Point: 5.0229

>AT192244 WP_204628137.1 NZ_CP069945:c3812139-3811783 [Escherichia coli]
MNYHSESGAIPEIPPCQHWGLKSTITPCFGARLVQEGDRLYFLADRAGFNGAFCDDDALYLDQAFPFILKQLELTLTSGE
LSPRHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp

>AT192244 NZ_CP092252:c2762116-2762050 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4NX47

Antitoxin

Source ID Structure

References