Detailed information of TA system TA192081

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2203585..2203807
• Replicon: chromosome
• Accession: NZ_CP069893
• Organism: Escherichia coli strain FDAARGOS_1286

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A829L523
• Locus tag: I6K16_RS10650
• Protein ID: WP_000170738.1
• Coordinates: 2203585..2203692 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2203741..2203807 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K16_RS10620	2198614..2200185	+	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
I6K16_RS10625	2200182..2200373	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6K16_RS10630	2200370..2202049	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
I6K16_RS10635	2202136..2202243	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K16_RS10640	2202619..2202726	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K16_RS10645	2203102..2203209	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K16_RS10650	2203585..2203692	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2203741..2203807	+	67	-	-	Antitoxin
I6K16_RS10655	2204168..2205439	+	1272	WP_001318103.1	aromatic amino acid transport family protein	-
I6K16_RS10660	2205469..2206473	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6K16_RS10665	2206470..2207453	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
I6K16_RS10670	2207464..2208366	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3864.67 Da
• Isoelectric Point: 9.0157

>T192081 WP_000170738.1 NZ_CP069893:c2203692-2203585 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Nucleotide

• Length: 108 bp

>T192081 NZ_CP092062:585819-586022 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT192081 NZ_CP069893:2203741-2203807 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A829L523

Antitoxin