Detailed information of TA system TA192005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1744486..1745300
• Replicon: chromosome
• Accession: NZ_CP069882
• Organism: Escherichia coli strain FDAARGOS_1289

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: I6K19_RS08350
• Protein ID: WP_001054376.1
• Coordinates: 1745043..1745300 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: I6K19_RS08345
• Protein ID: WP_001309181.1
• Coordinates: 1744486..1745031 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K19_RS08315 (1740177)	1740177..1741490	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
I6K19_RS08320 (1741502)	1741502..1741780	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
I6K19_RS08325 (1741777)	1741777..1742898	-	1122	WP_000010829.1	M42 family metallopeptidase	-
I6K19_RS08330 (1743143)	1743143..1743259	-	117	Protein_1639	VOC family protein	-
I6K19_RS08335 (1743297)	1743297..1743515	-	219	Protein_1640	hypothetical protein	-
I6K19_RS08340 (1743684)	1743684..1744430	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
I6K19_RS08345 (1744486)	1744486..1745031	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
I6K19_RS08350 (1745043)	1745043..1745300	-	258	WP_001054376.1	YjhX family toxin	Toxin
I6K19_RS27045 (1745791)	1745791..1745922	-	132	WP_001309182.1	hypothetical protein	-
I6K19_RS08360 (1746038)	1746038..1747278	+	1241	Protein_1645	helicase YjhR	-
I6K19_RS27050 (1747546)	1747546..1747751	-	206	Protein_1646	HNH endonuclease	-
I6K19_RS08365 (1747861)	1747861..1748841	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6K19_RS08370 (1748906)	1748906..1750012	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T192005 WP_001054376.1 NZ_CP069882:c1745300-1745043 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T192005 NZ_CP092037:c1476502-1476215 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT192005 WP_001309181.1 NZ_CP069882:c1745031-1744486 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT192005 NZ_CP092037:c1476741-1476502 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8