Detailed information of TA system TA191984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2196740..2197256
• Replicon: chromosome
• Accession: NZ_CP069873
• Organism: Klebsiella pneumoniae strain FDAARGOS_1323

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: I6K53_RS10650
• Protein ID: WP_004178374.1
• Coordinates: 2196972..2197256 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A919M0P8
• Locus tag: I6K53_RS10645
• Protein ID: WP_032434351.1
• Coordinates: 2196740..2196982 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K53_RS10630	2192769..2193509	+	741	WP_002886899.1	KDGP aldolase family protein	-
I6K53_RS10635	2193575..2194729	+	1155	WP_002886900.1	lactonase family protein	-
I6K53_RS10640	2194752..2196662	+	1911	WP_004152270.1	BglG family transcription antiterminator	-
I6K53_RS10645	2196740..2196982	+	243	WP_032434351.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6K53_RS10650	2196972..2197256	+	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6K53_RS10655	2197260..2197724	-	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
I6K53_RS10660	2197966..2200104	-	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
I6K53_RS10665	2200461..2201204	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
I6K53_RS10670	2201207..2201380	-	174	WP_032414379.1	hypothetical protein	-
I6K53_RS10675	2201465..2201773	+	309	WP_012737232.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T191984 WP_004178374.1 NZ_CP069873:2196972-2197256 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T191984 NZ_CP092014:c2553294-2553091 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9003.47 Da
• Isoelectric Point: 6.3340

>AT191984 WP_032434351.1 NZ_CP069873:2196740-2196982 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Nucleotide

• Length: 243 bp

>AT191984 NZ_CP092014:c2553683-2553315 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Structures

Toxin

• AlphaFold DB: A6THG1