Detailed information of TA system TA191851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 650250..650905
• Replicon: chromosome
• Accession: NZ_CP069820
• Organism: Bordetella pertussis strain FDAARGOS_1368

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: I6K98_RS03035
• Protein ID: WP_047122780.1
• Coordinates: 650654..650905 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: I6K98_RS03030
• Protein ID: WP_003809516.1
• Coordinates: 650250..650651 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K98_RS03000	645433..646455	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
I6K98_RS03005	646592..647629	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
I6K98_RS03010	647649..648839	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I6K98_RS03015	648842..649357	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I6K98_RS03020	649507..649986	-	480	WP_010930405.1	disulfide bond formation protein B	-
I6K98_RS03025	649994..650230	-	237	WP_010930404.1	membrane protein	-
I6K98_RS03030	650250..650651	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
I6K98_RS03035	650654..650905	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
I6K98_RS03040	650960..651841	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
I6K98_RS03045	652066..652512	+	447	WP_003819827.1	GFA family protein	-
I6K98_RS03050	652597..653661	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
I6K98_RS03055	653798..654379	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
I6K98_RS03060	654614..655744	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T191851 WP_047122780.1 NZ_CP069820:c650905-650654 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T191851 NZ_CP091965:c24656-24315 [Leptospira noguchii]
TTGGTAAAGAATAGAAATTATACTCCTGAAAAAGGAGATATTGTGTGGCTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT191851 WP_003809516.1 NZ_CP069820:c650651-650250 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT191851 NZ_CP091965:c24886-24650 [Leptospira noguchii]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6