Detailed information of TA system TA191848

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4377546..4378318
• Replicon: chromosome
• Accession: NZ_CP069815
• Organism: Raoultella planticola strain HH15

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2I8S4E2
• Locus tag: G9395_RS20705
• Protein ID: WP_065805889.1
• Coordinates: 4377546..4377935 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: G9395_RS20710
• Protein ID: WP_175364756.1
• Coordinates: 4377992..4378318 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9395_RS20675	4373089..4373790	-	702	WP_064793200.1	heavy metal response regulator transcription factor	-
G9395_RS20680	4373904..4374593	-	690	Protein_4061	efflux RND transporter periplasmic adaptor subunit	-
G9395_RS20685	4375406..4375699	-	294	WP_032689152.1	hypothetical protein	-
G9395_RS20690	4376026..4376211	-	186	WP_032696502.1	hypothetical protein	-
G9395_RS20695	4376254..4376445	+	192	Protein_4064	integrase	-
G9395_RS20700	4376614..4377459	-	846	WP_065805890.1	DUF4942 domain-containing protein	-
G9395_RS20705	4377546..4377935	-	390	WP_065805889.1	TA system toxin CbtA family protein	Toxin
G9395_RS20710	4377992..4378318	-	327	WP_175364756.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G9395_RS20715	4378376..4378597	-	222	WP_065805887.1	DUF987 domain-containing protein	-
G9395_RS20720	4378611..4379090	-	480	WP_065805886.1	DNA repair protein RadC	-
G9395_RS20725	4379102..4379545	-	444	WP_065805885.1	antirestriction protein	-
G9395_RS20730	4379625..4379882	-	258	WP_044349282.1	DUF905 domain-containing protein	-
G9395_RS20735	4379879..4380703	-	825	WP_065805884.1	DUF945 domain-containing protein	-
G9395_RS20740	4381241..4381873	+	633	WP_154955094.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14321.40 Da
• Isoelectric Point: 9.9883

>T191848 WP_065805889.1 NZ_CP069815:c4377935-4377546 [Raoultella planticola]
MQTKSSPLMRAASSRPSPVSVWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Nucleotide

• Length: 390 bp

>T191848 NZ_CP091959:100233-100574 [Leptospira noguchii]
TTGGTAAAGAATAGAAACTATACTCCTGAAAAAGGAGATATTGTGTGGCTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTCTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12054.78 Da
• Isoelectric Point: 6.9459

>AT191848 WP_175364756.1 NZ_CP069815:c4378318-4377992 [Raoultella planticola]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANVSGQFCDADLRHLDQAFPILLKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Nucleotide

• Length: 327 bp

>AT191848 NZ_CP091959:100003-100239 [Leptospira noguchii]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Structures

Toxin

• AlphaFold DB: A0A2I8S4E2