Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2413181..2413830 Replicon chromosome
Accession NZ_CP069798
Organism Paralysiella testudinis strain 26B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQU52_RS12320 Protein ID WP_230338771.1
Coordinates 2413181..2413579 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQU52_RS12325 Protein ID WP_230338772.1
Coordinates 2413591..2413830 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQU52_RS12305 (JQU52_12310) 2408437..2410842 + 2406 WP_230338769.1 SNF2-related protein -
JQU52_RS12310 (JQU52_12315) 2411169..2412275 + 1107 WP_230338770.1 DUF6094 domain-containing protein -
JQU52_RS12315 (JQU52_12320) 2412416..2413074 - 659 Protein_2405 transposase -
JQU52_RS12320 (JQU52_12325) 2413181..2413579 - 399 WP_230338771.1 type II toxin-antitoxin system VapC family toxin Toxin
JQU52_RS12325 (JQU52_12330) 2413591..2413830 - 240 WP_230338772.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JQU52_RS12330 (JQU52_12335) 2414124..2414762 + 639 WP_230338773.1 hypothetical protein -
JQU52_RS12335 (JQU52_12340) 2414912..2415646 + 735 WP_230338774.1 hypothetical protein -
JQU52_RS12340 (JQU52_12345) 2415746..2416051 - 306 WP_230338775.1 type II toxin-antitoxin system RelE/ParE family toxin -
JQU52_RS12345 (JQU52_12350) 2416053..2416361 - 309 WP_230338776.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JQU52_RS12350 (JQU52_12355) 2416491..2417797 - 1307 Protein_2412 IS5 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2412416..2412571 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-119)

Antitoxin

(9-45)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14196.38 Da        Isoelectric Point: 6.1191

>T191806 WP_230338771.1 NZ_CP069798:c2413579-2413181 [Paralysiella testudinis]
MLDTNMVSHVLKQQAAVMDRLQSVPMASLCISAITHAEISYGLAKKPDAHTLHRAVAEFLLRVAVLPFDEQAAQDYGLLK
AGIEGMGKSLAPLDMLIAAHAHSIGATLISNDQAFHKITGLAVQDWTQPDPD

Download         Length: 399 bp

>T191806 NZ_CP091913:5247287-5247511 [Nostoc sp. UHCC 0870]
ATGAGCAGTATTCCTGTTTTGAAACCTCAAGAGGTTGTTCGCATACTAGAAAATCTCGGTTTTGTAGAAGTTCGTCAAAG
AGGTTCACATAAGCAGTTTCGCCATGAAGACGGTCGAGCAACAACTGTTCCATTTCACAAAGGTCGTGATATTTCCCCCA
GACTGCTCAAACAGATTGCGAGTGACGTTGAATTGACAGTTGAAGAGTTTTTGGAATCCAGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9079.10 Da        Isoelectric Point: 5.0477

>AT191806 WP_230338772.1 NZ_CP069798:c2413830-2413591 [Paralysiella testudinis]
MQIAKLFNNGRSQAVRLPAAFRFDGDSVYIRRDKNGDVILSKRPSDWQGFIVAANQLDGETIERDLTAHNRDVFEDWPE

Download         Length: 240 bp

>AT191806 NZ_CP091913:5247074-5247283 [Nostoc sp. UHCC 0870]
ATGAAAACCTTTACTGCGGTTGTTGAGAAAGACATGGACACTGGTTTATATGTGGGCTACGTTCCTGGGTTTCCTGGCGC
GCATTCTCAAGCTGAAACTTTAGACGAGTTACAGATGAATCTGCGTGAAGTAATCGAGATGTTACTAGAGGATAAAAATC
CAACTTTCACAACTGAATTTGTTGGTACTCAGCAAATTGTCATTTCTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References