Detailed information of TA system TA191682

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 804959..805828
• Replicon: chromosome
• Accession: NZ_CP069707
• Organism: Escherichia coli strain E41

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1M1ISH3
• Locus tag: JSQ86_RS03960
• Protein ID: WP_039023580.1
• Coordinates: 804959..805369 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A0X5FMN2
• Locus tag: JSQ86_RS03965
• Protein ID: WP_039023579.1
• Coordinates: 805460..805828 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ86_RS03925	800267..800866	+	600	WP_001255034.1	type II secretion system minor pseudopilin GspJ	-
JSQ86_RS03930	800869..801846	+	978	WP_204098137.1	type II secretion system minor pseudopilin GspK	-
JSQ86_RS03935	801843..803021	+	1179	WP_000094962.1	type II secretion system protein GspL	-
JSQ86_RS03940	803023..803559	+	537	WP_000942785.1	GspM family type II secretion system protein YghD	-
JSQ86_RS03945	803929..804489	-	561	Protein_775	DUF4942 domain-containing protein	-
JSQ86_RS03950	804574..804771	-	198	WP_085975623.1	DUF957 domain-containing protein	-
JSQ86_RS03955	804826..804996	-	171	Protein_777	hypothetical protein	-
JSQ86_RS03960	804959..805369	-	411	WP_039023580.1	TA system toxin CbtA family protein	Toxin
JSQ86_RS03965	805460..805828	-	369	WP_039023579.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JSQ86_RS03970	805878..806152	-	275	Protein_780	antitoxin of the YeeV-YeeU toxin-antitoxin system	-
JSQ86_RS03975	806250..806510	-	261	WP_032303908.1	hypothetical protein	-
JSQ86_RS03980	806525..806746	-	222	WP_000692315.1	DUF987 domain-containing protein	-
JSQ86_RS03985	806809..807285	-	477	WP_122988606.1	RadC family protein	-
JSQ86_RS03990	807301..807780	-	480	WP_000860074.1	antirestriction protein	-
JSQ86_RS03995	807862..808680	-	819	WP_001234688.1	DUF945 domain-containing protein	-
JSQ86_RS04000	808866..809750	-	885	WP_000010380.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15253.38 Da
• Isoelectric Point: 7.2150

>T191682 WP_039023580.1 NZ_CP069707:c805369-804959 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITLGSIRGRNDETFPDAGSRQR

Nucleotide

• Length: 411 bp

>T191682 NZ_CP091878:c4176107-4175823 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13672.49 Da
• Isoelectric Point: 6.7393

>AT191682 WP_039023579.1 NZ_CP069707:c805828-805460 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT191682 NZ_CP091878:c4176339-4176097 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A1M1ISH3

Antitoxin

• AlphaFold DB: A0A0X5FMN2