Detailed information of TA system TA191675

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yeeU/CbtA-CbeA
• Location: 4103893..4104594
• Replicon: chromosome
• Accession: NZ_CP069706
• Organism: Escherichia coli strain ECY44

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: A0A3L9JQV5
• Locus tag: JR341_RS22835
• Protein ID: WP_038977124.1
• Coordinates: 4103893..4104228 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A3L1KVZ6
• Locus tag: JR341_RS22840
• Protein ID: WP_000939437.1
• Coordinates: 4104259..4104594 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JR341_RS22810	4099867..4100847	+	981	WP_057075671.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
JR341_RS22815	4100855..4100977	-	123	WP_001338066.1	hypothetical protein	-
JR341_RS22820	4101524..4102471	-	948	WP_038977127.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JR341_RS22825	4102464..4102859	-	396	WP_038977126.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
JR341_RS22830	4102929..4103762	-	834	WP_038977125.1	DUF4942 domain-containing protein	-
JR341_RS22835	4103893..4104228	-	336	WP_038977124.1	TA system toxin CbtA family protein	Toxin
JR341_RS22840	4104259..4104594	-	336	WP_000939437.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JR341_RS22845	4104594..4105067	-	474	WP_038977123.1	DNA repair protein RadC	-
JR341_RS22850	4105097..4105915	-	819	WP_033800492.1	DUF945 domain-containing protein	-
JR341_RS22855	4106151..4107104	-	954	WP_038977122.1	hypothetical protein	-
JR341_RS22860	4107697..4108311	+	615	WP_000772911.1	inovirus Gp2 family protein	-
JR341_RS22865	4108429..4108647	+	219	WP_001064742.1	AlpA family phage regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (10-110)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12802.79 Da
• Isoelectric Point: 8.9372

>T191675 WP_038977124.1 NZ_CP069706:c4104228-4103893 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCHNTP

Nucleotide

• Length: 336 bp

>T191675 NZ_CP091878:879038-879451 [Salmonella enterica subsp. enterica serovar Tennessee]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGCCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12556.56 Da
• Isoelectric Point: 7.6977

>AT191675 WP_000939437.1 NZ_CP069706:c4104594-4104259 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 336 bp

>AT191675 NZ_CP091878:878791-879057 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGCAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A3L9JQV5

Antitoxin

• AlphaFold DB: A0A3L1KVZ6