Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 612454..613253 Replicon chromosome
Accession NZ_CP069692
Organism Escherichia coli H20 strain MIN6

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag JSU10_RS02980 Protein ID WP_000347253.1
Coordinates 612454..612918 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag JSU10_RS02985 Protein ID WP_024251361.1
Coordinates 612918..613253 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU10_RS02950 (607455) 607455..607889 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
JSU10_RS02955 (607907) 607907..608785 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
JSU10_RS02960 (608775) 608775..609554 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
JSU10_RS02965 (609565) 609565..610038 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JSU10_RS02970 (610061) 610061..611341 - 1281 WP_000681910.1 tagatose-bisphosphate aldolase subunit KbaZ -
JSU10_RS02975 (611590) 611590..612399 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JSU10_RS02980 (612454) 612454..612918 - 465 WP_000347253.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JSU10_RS02985 (612918) 612918..613253 - 336 WP_024251361.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JSU10_RS02990 (613402) 613402..614973 - 1572 WP_001273766.1 galactarate dehydratase -
JSU10_RS02995 (615348) 615348..616682 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
JSU10_RS03000 (616698) 616698..617468 + 771 WP_001058226.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17764.14 Da        Isoelectric Point: 9.4947

>T191612 WP_000347253.1 NZ_CP069692:c612918-612454 [Escherichia coli H20]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEETH

Download         Length: 465 bp

>T191612 NZ_CP091839:c981124-981021 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12348.90 Da        Isoelectric Point: 4.8616

>AT191612 WP_024251361.1 NZ_CP069692:c613253-612918 [Escherichia coli H20]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
SQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT191612 NZ_CP091839:980983-981254 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References