Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3510742..3511000 Replicon chromosome
Accession NZ_CP069636
Organism Escherichia coli strain SSGw2

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JSQ96_RS16695 Protein ID WP_000809168.1
Coordinates 3510742..3510894 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3510943..3511000 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ96_RS16675 3505987..3506700 - 714 WP_001102391.1 acidic protein MsyB -
JSQ96_RS16680 3506726..3507130 - 405 WP_000843687.1 DUF2541 family protein -
JSQ96_RS16685 3507502..3509418 + 1917 WP_000516135.1 molecular chaperone DnaK -
JSQ96_RS16690 3509507..3510637 + 1131 WP_001118465.1 molecular chaperone DnaJ -
JSQ96_RS16695 3510742..3510894 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3510943..3511000 + 58 - - Antitoxin
JSQ96_RS16700 3511509..3512270 + 762 WP_001274832.1 outer membrane protein OmpK -
JSQ96_RS16705 3512290..3513783 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
JSQ96_RS16710 3513912..3515171 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T191431 WP_000809168.1 NZ_CP069636:c3510894-3510742 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T191431 NZ_CP091704:216637-216744 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT191431 NZ_CP069636:3510943-3511000 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References