Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4684595..4685396 Replicon chromosome
Accession NZ_CP069627
Organism Escherichia coli strain ESM1.4

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag JSQ89_RS22240 Protein ID WP_000854739.1
Coordinates 4685016..4685396 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag JSQ89_RS22235 Protein ID WP_001285482.1
Coordinates 4684595..4684969 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ89_RS22200 (4680683) 4680683..4681138 + 456 WP_000581502.1 IrmA family protein -
JSQ89_RS22205 (4681281) 4681281..4681370 + 90 WP_230607454.1 DUF905 family protein -
JSQ89_RS22210 (4681549) 4681549..4682370 + 822 WP_001234710.1 DUF932 domain-containing protein -
JSQ89_RS22215 (4682633) 4682633..4683106 + 474 WP_000855076.1 antirestriction protein -
JSQ89_RS22220 (4683122) 4683122..4683598 + 477 WP_001186170.1 RadC family protein -
JSQ89_RS22225 (4683661) 4683661..4683882 + 222 WP_000692312.1 DUF987 domain-containing protein -
JSQ89_RS22230 (4683901) 4683901..4684545 + 645 WP_000094915.1 hypothetical protein -
JSQ89_RS22235 (4684595) 4684595..4684969 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSQ89_RS22240 (4685016) 4685016..4685396 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
JSQ89_RS22245 (4685393) 4685393..4685881 + 489 WP_001054232.1 DUF5983 family protein -
JSQ89_RS22250 (4685901) 4685901..4686098 + 198 WP_000772027.1 DUF957 domain-containing protein -
JSQ89_RS22255 (4686183) 4686183..4687026 + 844 Protein_4347 DUF4942 domain-containing protein -
JSQ89_RS22265 (4687497) 4687497..4688435 + 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
JSQ89_RS22270 (4688490) 4688490..4689227 + 738 WP_000283664.1 zinc-binding phosphatase -
JSQ89_RS22275 (4689251) 4689251..4689805 + 555 WP_001001909.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4659827..4685396 25569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T191355 WP_000854739.1 NZ_CP069627:4685016-4685396 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T191355 NZ_CP091685:74727-75143 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT191355 WP_001285482.1 NZ_CP069627:4684595-4684969 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT191355 NZ_CP091685:74500-74730 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References