Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3746591..3747389 Replicon chromosome
Accession NZ_CP069627
Organism Escherichia coli strain ESM1.4

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag JSQ89_RS17820 Protein ID WP_000854730.1
Coordinates 3746591..3746968 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag JSQ89_RS17825 Protein ID WP_001285481.1
Coordinates 3747015..3747389 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ89_RS17790 (3741735) 3741735..3743139 + 1405 Protein_3474 IS66 family transposase -
JSQ89_RS17795 (3743393) 3743393..3744526 - 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
JSQ89_RS17800 (3744590) 3744590..3744715 + 126 WP_001704224.1 transposase -
JSQ89_RS17805 (3744699) 3744699..3744887 + 189 Protein_3477 IS66 family transposase -
JSQ89_RS17810 (3745035) 3745035..3746023 + 989 Protein_3478 IS630 family transposase -
JSQ89_RS17815 (3746102) 3746102..3746594 - 493 Protein_3479 DUF5983 family protein -
JSQ89_RS17820 (3746591) 3746591..3746968 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
JSQ89_RS17825 (3747015) 3747015..3747389 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSQ89_RS17830 (3747439) 3747439..3748083 - 645 WP_000086759.1 hypothetical protein -
JSQ89_RS17835 (3748102) 3748102..3748323 - 222 WP_000692315.1 DUF987 domain-containing protein -
JSQ89_RS17840 (3748386) 3748386..3748862 - 477 WP_001313574.1 RadC family protein -
JSQ89_RS17845 (3748878) 3748878..3749351 - 474 WP_001313575.1 antirestriction protein -
JSQ89_RS17850 (3749445) 3749445..3749690 - 246 WP_001164966.1 hypothetical protein -
JSQ89_RS17855 (3749690) 3749690..3750511 - 822 WP_024199417.1 DUF932 domain-containing protein -
JSQ89_RS17860 (3750611) 3750611..3750844 - 234 WP_001213776.1 DUF905 family protein -
JSQ89_RS17865 (3750962) 3750962..3751414 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T191353 WP_000854730.1 NZ_CP069627:c3746968-3746591 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T191353 NZ_CP091684:2062-2337 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAAGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT191353 WP_001285481.1 NZ_CP069627:c3747389-3747015 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT191353 NZ_CP091684:1778-2062 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References