Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 3746591..3747389 | Replicon | chromosome |
Accession | NZ_CP069621 | ||
Organism | Escherichia coli strain PBP5 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | Q8VRA6 |
Locus tag | JSQ88_RS17820 | Protein ID | WP_000854730.1 |
Coordinates | 3746591..3746968 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A0P0SQV8 |
Locus tag | JSQ88_RS17825 | Protein ID | WP_001285481.1 |
Coordinates | 3747015..3747389 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JSQ88_RS17790 (3741735) | 3741735..3743139 | + | 1405 | Protein_3473 | IS66 family transposase | - |
JSQ88_RS17795 (3743393) | 3743393..3744526 | - | 1134 | WP_000555401.1 | IS110-like element ISEc45 family transposase | - |
JSQ88_RS17800 (3744590) | 3744590..3744715 | + | 126 | WP_001704224.1 | transposase | - |
JSQ88_RS17805 (3744699) | 3744699..3744887 | + | 189 | Protein_3476 | IS66 family transposase | - |
JSQ88_RS17810 (3745035) | 3745035..3746023 | + | 989 | Protein_3477 | IS630 family transposase | - |
JSQ88_RS17815 (3746102) | 3746102..3746594 | - | 493 | Protein_3478 | DUF5983 family protein | - |
JSQ88_RS17820 (3746591) | 3746591..3746968 | - | 378 | WP_000854730.1 | TA system toxin CbtA family protein | Toxin |
JSQ88_RS17825 (3747015) | 3747015..3747389 | - | 375 | WP_001285481.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
JSQ88_RS17830 (3747439) | 3747439..3748083 | - | 645 | WP_000086759.1 | hypothetical protein | - |
JSQ88_RS17835 (3748102) | 3748102..3748323 | - | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
JSQ88_RS17840 (3748386) | 3748386..3748862 | - | 477 | WP_001313574.1 | RadC family protein | - |
JSQ88_RS17845 (3748878) | 3748878..3749351 | - | 474 | WP_001313575.1 | antirestriction protein | - |
JSQ88_RS17850 (3749445) | 3749445..3749690 | - | 246 | WP_001164966.1 | hypothetical protein | - |
JSQ88_RS17855 (3749690) | 3749690..3750511 | - | 822 | WP_024199417.1 | DUF932 domain-containing protein | - |
JSQ88_RS17860 (3750611) | 3750611..3750844 | - | 234 | WP_001213776.1 | DUF905 family protein | - |
JSQ88_RS17865 (3750962) | 3750962..3751414 | - | 453 | WP_000682723.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14212.21 Da Isoelectric Point: 7.2923
>T191299 WP_000854730.1 NZ_CP069621:c3746968-3746591 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR
Download Length: 378 bp
>T191299 NZ_CP091673:3807147-3807524 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13817.53 Da Isoelectric Point: 4.7511
>AT191299 WP_001285481.1 NZ_CP069621:c3747389-3747015 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT191299 NZ_CP091673:3806726-3807100 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H2V671 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P0SQV8 |