Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3746591..3747389 Replicon chromosome
Accession NZ_CP069621
Organism Escherichia coli strain PBP5

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag JSQ88_RS17820 Protein ID WP_000854730.1
Coordinates 3746591..3746968 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag JSQ88_RS17825 Protein ID WP_001285481.1
Coordinates 3747015..3747389 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ88_RS17790 (3741735) 3741735..3743139 + 1405 Protein_3473 IS66 family transposase -
JSQ88_RS17795 (3743393) 3743393..3744526 - 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
JSQ88_RS17800 (3744590) 3744590..3744715 + 126 WP_001704224.1 transposase -
JSQ88_RS17805 (3744699) 3744699..3744887 + 189 Protein_3476 IS66 family transposase -
JSQ88_RS17810 (3745035) 3745035..3746023 + 989 Protein_3477 IS630 family transposase -
JSQ88_RS17815 (3746102) 3746102..3746594 - 493 Protein_3478 DUF5983 family protein -
JSQ88_RS17820 (3746591) 3746591..3746968 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
JSQ88_RS17825 (3747015) 3747015..3747389 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSQ88_RS17830 (3747439) 3747439..3748083 - 645 WP_000086759.1 hypothetical protein -
JSQ88_RS17835 (3748102) 3748102..3748323 - 222 WP_000692315.1 DUF987 domain-containing protein -
JSQ88_RS17840 (3748386) 3748386..3748862 - 477 WP_001313574.1 RadC family protein -
JSQ88_RS17845 (3748878) 3748878..3749351 - 474 WP_001313575.1 antirestriction protein -
JSQ88_RS17850 (3749445) 3749445..3749690 - 246 WP_001164966.1 hypothetical protein -
JSQ88_RS17855 (3749690) 3749690..3750511 - 822 WP_024199417.1 DUF932 domain-containing protein -
JSQ88_RS17860 (3750611) 3750611..3750844 - 234 WP_001213776.1 DUF905 family protein -
JSQ88_RS17865 (3750962) 3750962..3751414 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T191299 WP_000854730.1 NZ_CP069621:c3746968-3746591 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T191299 NZ_CP091673:3807147-3807524 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT191299 WP_001285481.1 NZ_CP069621:c3747389-3747015 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT191299 NZ_CP091673:3806726-3807100 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2V671


Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References