Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4839809..4840644 Replicon chromosome
Accession NZ_CP069559
Organism Escherichia coli strain FDAARGOS_1259

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VR61
Locus tag I6J89_RS23470 Protein ID WP_000854747.1
Coordinates 4840267..4840644 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3P1Z1K5
Locus tag I6J89_RS23465 Protein ID WP_021538665.1
Coordinates 4839809..4840177 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J89_RS23430 4835543..4836427 + 885 WP_000010387.1 50S ribosome-binding GTPase -
I6J89_RS23435 4836546..4837223 + 678 WP_001097364.1 hypothetical protein -
I6J89_RS23440 4837229..4837462 + 234 WP_021538212.1 DUF905 family protein -
I6J89_RS23445 4837563..4838381 + 819 WP_001234693.1 DUF945 domain-containing protein -
I6J89_RS23450 4838473..4838958 + 486 WP_021566656.1 antirestriction protein -
I6J89_RS23455 4838974..4839450 + 477 WP_001186727.1 RadC family protein -
I6J89_RS23460 4839513..4839734 + 222 WP_001825901.1 DUF987 domain-containing protein -
I6J89_RS23465 4839809..4840177 + 369 WP_021538665.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J89_RS23470 4840267..4840644 + 378 WP_000854747.1 TA system toxin CbtA family protein Toxin
I6J89_RS23475 4840641..4841129 + 489 WP_059342216.1 hypothetical protein -
I6J89_RS23480 4841141..4841338 + 198 WP_000839291.1 DUF957 domain-containing protein -
I6J89_RS23485 4841423..4842277 + 855 WP_001588930.1 DUF4942 domain-containing protein -
I6J89_RS23490 4843014..4844552 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4827990..4852365 24375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14095.03 Da        Isoelectric Point: 6.8524

>T190923 WP_000854747.1 NZ_CP069559:4840267-4840644 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T190923 NZ_CP091573:40481-40633 [Salmonella enterica]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13465.18 Da        Isoelectric Point: 6.2015

>AT190923 WP_021538665.1 NZ_CP069559:4839809-4840177 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNQLHYLADHAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Download         Length: 369 bp

>AT190923 NZ_CP091573:c40429-40369 [Salmonella enterica]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VFZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A3P1Z1K5

References