Detailed information of TA system TA190900

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1246866..1247700
• Replicon: chromosome
• Accession: NZ_CP069559
• Organism: Escherichia coli strain FDAARGOS_1259

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A8E0IX31
• Locus tag: I6J89_RS05945
• Protein ID: WP_000854689.1
• Coordinates: 1246866..1247243 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1X3JHN3
• Locus tag: I6J89_RS05950
• Protein ID: WP_001285598.1
• Coordinates: 1247320..1247700 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J89_RS05915	1243247..1243417	-	171	Protein_1142	IS110 family transposase	-
I6J89_RS05920	1243888..1244781	-	894	WP_059342195.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I6J89_RS05925	1244774..1245169	-	396	WP_000208383.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
I6J89_RS05930	1245238..1246083	-	846	WP_023281696.1	DUF4942 domain-containing protein	-
I6J89_RS05935	1246168..1246365	-	198	WP_000839293.1	DUF957 domain-containing protein	-
I6J89_RS05940	1246382..1246869	-	488	Protein_1147	hypothetical protein	-
I6J89_RS05945	1246866..1247243	-	378	WP_000854689.1	TA system toxin CbtA family protein	Toxin
I6J89_RS05950	1247320..1247700	-	381	WP_001285598.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6J89_RS05955	1247750..1248394	-	645	WP_000094916.1	hypothetical protein	-
I6J89_RS05960	1248413..1248634	-	222	WP_000692329.1	DUF987 domain-containing protein	-
I6J89_RS05965	1248697..1249173	-	477	WP_001186726.1	RadC family protein	-
I6J89_RS05970	1249189..1249674	-	486	WP_059342223.1	antirestriction protein	-
I6J89_RS05975	1249729..1250547	-	819	WP_001234620.1	DUF945 domain-containing protein	-
I6J89_RS05980	1250648..1250857	-	210	WP_032142237.1	DUF905 family protein	-
I6J89_RS05985	1250962..1251417	-	456	WP_000581502.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14042.07 Da
• Isoelectric Point: 9.1510

>T190900 WP_000854689.1 NZ_CP069559:c1247243-1246866 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T190900 NZ_CP091569:3706275-3706550 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13927.72 Da
• Isoelectric Point: 4.7959

>AT190900 WP_001285598.1 NZ_CP069559:c1247700-1247320 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT190900 NZ_CP091569:c3706540-3706118 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Antitoxin

• AlphaFold DB: A0A1X3JHN3