Detailed information of TA system TA190784

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4698471..4699306
• Replicon: chromosome
• Accession: NZ_CP069522
• Organism: Escherichia coli strain FDAARGOS_1267

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A377K286
• Locus tag: I6J97_RS22775
• Protein ID: WP_001519089.1
• Coordinates: 4698929..4699306 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A085P7I7
• Locus tag: I6J97_RS22770
• Protein ID: WP_001327592.1
• Coordinates: 4698471..4698839 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J97_RS22735	4694056..4694736	+	681	WP_001519095.1	WYL domain-containing protein	-
I6J97_RS22740	4694884..4695561	+	678	WP_001519094.1	hypothetical protein	-
I6J97_RS22745	4695567..4695800	+	234	WP_001278282.1	DUF905 family protein	-
I6J97_RS22750	4695890..4696708	+	819	WP_021524998.1	DUF945 domain-containing protein	-
I6J97_RS22755	4697047..4697526	+	480	WP_000706981.1	antirestriction protein	-
I6J97_RS22760	4697542..4698018	+	477	WP_001186727.1	RadC family protein	-
I6J97_RS22765	4698087..4698308	+	222	WP_000692323.1	DUF987 domain-containing protein	-
I6J97_RS22770	4698471..4698839	+	369	WP_001327592.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6J97_RS22775	4698929..4699306	+	378	WP_001519089.1	TA system toxin CbtA family protein	Toxin
I6J97_RS22780	4699303..4699791	+	489	WP_001519085.1	hypothetical protein	-
I6J97_RS22785	4699803..4700000	+	198	WP_001519084.1	DUF957 domain-containing protein	-
I6J97_RS22790	4700085..4700927	+	843	WP_001519083.1	DUF4942 domain-containing protein	-
I6J97_RS22795	4701676..4703214	+	1539	WP_001187191.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	papX / sfaY / sfaH / sfaS / sfaG / focD / focC / focI / focA / sfaB / sfaC / cnf1 / hlyD / hlyB / hlyA / hlyC / sfaX / papF / papE / papK / papJ / papD / papC / papH / papA / papB / papI	4590533..4711027	120494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14333.29 Da
• Isoelectric Point: 8.2918

>T190784 WP_001519089.1 NZ_CP069522:4698929-4699306 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T190784 NZ_CP091547:c3861775-3861377 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13901.65 Da
• Isoelectric Point: 6.3165

>AT190784 WP_001327592.1 NZ_CP069522:4698471-4698839 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT190784 NZ_CP091547:c3862002-3861775 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A377K286

Antitoxin

• AlphaFold DB: A0A085P7I7