Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2960979..2961780 Replicon chromosome
Accession NZ_CP069522
Organism Escherichia coli strain FDAARGOS_1267

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag I6J97_RS14240 Protein ID WP_000854739.1
Coordinates 2960979..2961359 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag I6J97_RS14245 Protein ID WP_001285482.1
Coordinates 2961406..2961780 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J97_RS14200 2956149..2956433 - 285 WP_069722514.1 hypothetical protein -
I6J97_RS14205 2956559..2957116 - 558 WP_176252291.1 hypothetical protein -
I6J97_RS14210 2957481..2957885 - 405 Protein_2791 zinc-binding phosphatase -
I6J97_RS14215 2957940..2958878 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
I6J97_RS14225 2959365..2960192 - 828 WP_001518536.1 DUF4942 domain-containing protein -
I6J97_RS14230 2960277..2960474 - 198 WP_000772027.1 DUF957 domain-containing protein -
I6J97_RS14235 2960494..2960982 - 489 WP_001518535.1 hypothetical protein -
I6J97_RS14240 2960979..2961359 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
I6J97_RS14245 2961406..2961780 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J97_RS14250 2961830..2962474 - 645 WP_000086759.1 hypothetical protein -
I6J97_RS14255 2962493..2962714 - 222 WP_000692315.1 DUF987 domain-containing protein -
I6J97_RS14260 2962777..2963253 - 477 WP_001313574.1 RadC family protein -
I6J97_RS14265 2963269..2963742 - 474 WP_001313575.1 antirestriction protein -
I6J97_RS14270 2963836..2964081 - 246 WP_001164966.1 hypothetical protein -
I6J97_RS14275 2964081..2964899 - 819 WP_001560884.1 DUF945 domain-containing protein -
I6J97_RS14280 2965054..2965188 - 135 WP_032144430.1 DUF905 family protein -
I6J97_RS14285 2965289..2965744 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2920025..2963742 43717


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T190776 WP_000854739.1 NZ_CP069522:c2961359-2960979 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T190776 NZ_CP091547:360187-360678 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT190776 WP_001285482.1 NZ_CP069522:c2961780-2961406 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT190776 NZ_CP091547:359897-360190 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References