Detailed information of TA system TA190755

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4781232..4781490
• Replicon: chromosome
• Accession: NZ_CP069517
• Organism: Escherichia coli strain FDAARGOS_1262

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6J92_RS22945
• Protein ID: WP_000809168.1
• Coordinates: 4781232..4781384 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4781433..4781490 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J92_RS22925	4776476..4777189	-	714	WP_001102393.1	acidic protein MsyB	-
I6J92_RS22930	4777215..4777619	-	405	WP_000843687.1	DUF2541 family protein	-
I6J92_RS22935	4777992..4779908	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6J92_RS22940	4779997..4781127	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6J92_RS22945	4781232..4781384	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	4781433..4781490	+	58	-	-	Antitoxin
I6J92_RS22950	4781999..4782760	+	762	WP_001274832.1	hypothetical protein	-
I6J92_RS22955	4782780..4784273	+	1494	WP_001468392.1	sulfatase-like hydrolase/transferase	-
I6J92_RS22960	4784402..4785661	+	1260	WP_204148035.1	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T190755 WP_000809168.1 NZ_CP069517:c4781384-4781232 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T190755 NZ_CP091542:c4249602-4249318 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT190755 NZ_CP069517:4781433-4781490 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin