Detailed information of TA system TA190507

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokA/Ldr(toxin)
• Location: 3652436..3652660
• Replicon: chromosome
• Accession: NZ_CP069453
• Organism: Escherichia coli strain FDAARGOS_1254

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A366YNB7
• Locus tag: I6J84_RS17440
• Protein ID: WP_001441942.1
• Coordinates: 3652436..3652543 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3652599..3652660 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J84_RS17415	3648280..3649362	+	1083	WP_000804726.1	peptide chain release factor 1	-
I6J84_RS17420	3649362..3650195	+	834	WP_000456476.1	peptide chain release factor N(5)-glutamine methyltransferase	-
I6J84_RS17425	3650192..3650584	+	393	WP_000200375.1	invasion regulator SirB2	-
I6J84_RS17430	3650588..3651397	+	810	WP_001257054.1	invasion regulator SirB1	-
I6J84_RS17435	3651433..3652287	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
I6J84_RS17440	3652436..3652543	-	108	WP_001441942.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3652599..3652660	+	62	NuclAT_12	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_12	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_12	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_12	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_13	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_13	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_13	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_13	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_14	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_14	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_14	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_14	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_15	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_15	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_15	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_15	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_16	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_16	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_16	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_16	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_17	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_17	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_17	-	Antitoxin
-	3652599..3652660	+	62	NuclAT_17	-	Antitoxin
-	3652599..3652661	+	63	NuclAT_10	-	-
-	3652599..3652661	+	63	NuclAT_10	-	-
-	3652599..3652661	+	63	NuclAT_10	-	-
-	3652599..3652661	+	63	NuclAT_10	-	-
-	3652599..3652661	+	63	NuclAT_5	-	-
-	3652599..3652661	+	63	NuclAT_5	-	-
-	3652599..3652661	+	63	NuclAT_5	-	-
-	3652599..3652661	+	63	NuclAT_5	-	-
-	3652599..3652661	+	63	NuclAT_6	-	-
-	3652599..3652661	+	63	NuclAT_6	-	-
-	3652599..3652661	+	63	NuclAT_6	-	-
-	3652599..3652661	+	63	NuclAT_6	-	-
-	3652599..3652661	+	63	NuclAT_7	-	-
-	3652599..3652661	+	63	NuclAT_7	-	-
-	3652599..3652661	+	63	NuclAT_7	-	-
-	3652599..3652661	+	63	NuclAT_7	-	-
-	3652599..3652661	+	63	NuclAT_8	-	-
-	3652599..3652661	+	63	NuclAT_8	-	-
-	3652599..3652661	+	63	NuclAT_8	-	-
-	3652599..3652661	+	63	NuclAT_8	-	-
-	3652599..3652661	+	63	NuclAT_9	-	-
-	3652599..3652661	+	63	NuclAT_9	-	-
-	3652599..3652661	+	63	NuclAT_9	-	-
-	3652599..3652661	+	63	NuclAT_9	-	-
I6J84_RS17445	3652953..3654053	-	1101	WP_000063608.1	sodium-potassium/proton antiporter ChaA	-
I6J84_RS17450	3654323..3654553	+	231	WP_001146435.1	putative cation transport regulator ChaB	-
I6J84_RS17455	3654711..3655406	+	696	WP_024176023.1	glutathione-specific gamma-glutamylcyclotransferase	-
I6J84_RS17460	3655450..3655803	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-
I6J84_RS17465	3655988..3657382	+	1395	WP_000085918.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3951.74 Da
• Isoelectric Point: 11.4779

>T190507 WP_001441942.1 NZ_CP069453:c3652543-3652436 [Escherichia coli]
MTLAQFAVIFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T190507 NZ_CP091412:431600-431962 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 62 bp

>AT190507 NZ_CP069453:3652599-3652660 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A366YNB7

Antitoxin