Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1588803..1589458 Replicon chromosome
Accession NZ_CP069437
Organism Moraxella osloensis strain FDAARGOS_1202

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6J32_RS07660 Protein ID WP_135889367.1
Coordinates 1589057..1589458 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6J32_RS07655 Protein ID WP_160002672.1
Coordinates 1588803..1589039 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J32_RS07640 1583865..1585526 + 1662 WP_204155135.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
I6J32_RS07645 1585967..1586146 - 180 WP_036592470.1 hypothetical protein -
I6J32_RS07650 1586367..1588523 - 2157 WP_204156683.1 ATP-dependent DNA helicase RecG -
I6J32_RS07655 1588803..1589039 + 237 WP_160002672.1 antitoxin Antitoxin
I6J32_RS07660 1589057..1589458 + 402 WP_135889367.1 tRNA(fMet)-specific endonuclease VapC Toxin
I6J32_RS07665 1589462..1590337 + 876 WP_204155136.1 patatin-like phospholipase family protein -
I6J32_RS07670 1590412..1590945 - 534 WP_204155137.1 hypothetical protein -
I6J32_RS07675 1591446..1592804 + 1359 WP_204156684.1 amino-acid N-acetyltransferase -
I6J32_RS07680 1592902..1593156 - 255 WP_204155138.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
I6J32_RS07685 1593266..1594061 + 796 WP_204155139.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15001.13 Da        Isoelectric Point: 6.8695

>T190342 WP_135889367.1 NZ_CP069437:1589057-1589458 [Moraxella osloensis]
MLTFMLDTNIAIHVIKQRPIAALNKFNQYAARICVSSITVAELYFGAENSQNMAKNLVQVDDFLSRLVILDYDSQAASHY
GNIYADLTKKGNVISENDMHIAGHARSRGLILVTNNLREFERVEGLRLDNWVS

Download         Length: 402 bp

>T190342 NZ_CP091300:1588357-1588575 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8998.14 Da        Isoelectric Point: 7.2032

>AT190342 WP_160002672.1 NZ_CP069437:1588803-1589039 [Moraxella osloensis]
MTQASVFFNNRTQAVRLPADMRFADDIKHVHIRKVGNERILTPISNVWDSFFIAKDPVSDDFMAQRSNAPISQRESFD

Download         Length: 237 bp

>AT190342 NZ_CP091300:1587955-1588329 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References