Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 273342..274018 Replicon plasmid unnamed2
Accession NZ_CP069304
Organism Shinella sp. PSBB067

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQ506_RS24985 Protein ID WP_203320428.1
Coordinates 273593..274018 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQ506_RS24980 Protein ID WP_203320427.1
Coordinates 273342..273596 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ506_RS24960 269045..269635 + 591 WP_203320425.1 DedA family protein -
JQ506_RS24965 269884..270894 + 1011 WP_203315665.1 IS30 family transposase -
JQ506_RS24970 271050..271411 + 362 Protein_251 IS30 family transposase -
JQ506_RS24975 271800..271964 - 165 WP_203320426.1 hypothetical protein -
JQ506_RS24980 273342..273596 + 255 WP_203320427.1 plasmid stabilization protein Antitoxin
JQ506_RS24985 273593..274018 + 426 WP_203320428.1 PIN domain-containing protein Toxin
JQ506_RS24990 274038..274298 - 261 WP_203320429.1 WGR domain-containing protein -
JQ506_RS24995 274759..275988 + 1230 WP_203320491.1 plasmid partitioning protein RepA -
JQ506_RS25000 275988..277061 + 1074 WP_203320492.1 plasmid partitioning protein RepB -
JQ506_RS25005 277373..278587 + 1215 WP_203320430.1 replication initiation protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katB 1..684612 684612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14627.82 Da        Isoelectric Point: 4.4857

>T190118 WP_203320428.1 NZ_CP069304:273593-274018 [Shinella sp. PSBB067]
MILLDTNVVCEAMKPEPAAAVIAWLYGQVAETAFLSSVIIAGLMSGIGALPDGRRKQGPAEALDGVTEIFEGRILPFDVA
AARRYADLAVEARAASRDFPTPDGYIAAIAAAHGFAIATRSKSAFDAAGLVVIDPWATPVG

Download         Length: 426 bp

>T190118 NZ_CP091100:1993411-1993677 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9051.30 Da        Isoelectric Point: 11.0140

>AT190118 WP_203320427.1 NZ_CP069304:273342-273596 [Shinella sp. PSBB067]
MPAVTIGNLSAATHRALKVRAAHHGRSTEAEMREILESAARPQARLRPGSALVERSRRLGLTSEDVAGRDETLARAPVEP
MGLE

Download         Length: 255 bp

>AT190118 NZ_CP091100:1993148-1993411 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References