Detailed information of TA system TA190111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 67241..67849
• Replicon: chromosome
• Accession: NZ_CP069278
• Organism: Bifidobacterium longum strain HN001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3BGL7
• Locus tag: JQN89_RS00370
• Protein ID: WP_007056255.1
• Coordinates: 67241..67576 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3BGP0
• Locus tag: JQN89_RS00375
• Protein ID: WP_007056990.1
• Coordinates: 67580..67849 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN89_RS00330	62338..63012	+	675	WP_203385598.1	YidC/Oxa1 family membrane protein insertase	-
JQN89_RS00335	63114..63734	+	621	WP_007054239.1	NUDIX hydrolase	-
JQN89_RS00340	63763..64086	+	324	WP_012471871.1	amidohydrolase	-
JQN89_RS00345	64736..65029	-	294	WP_012471870.1	hypothetical protein	-
JQN89_RS00350	65122..65763	-	642	WP_007056262.1	hypothetical protein	-
JQN89_RS00355	65977..66156	+	180	WP_007056286.1	antitoxin VbhA family protein	-
JQN89_RS00360	66153..66737	+	585	WP_007056278.1	Fic family protein	-
JQN89_RS00365	66940..67224	-	285	WP_007056282.1	hypothetical protein	-
JQN89_RS00370	67241..67576	-	336	WP_007056255.1	type II toxin-antitoxin system YafQ family toxin	Toxin
JQN89_RS00375	67580..67849	-	270	WP_007056990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JQN89_RS00380	68034..69203	-	1170	WP_007056274.1	ABC transporter permease	-
JQN89_RS00385	69200..69845	-	646	Protein_76	ABC transporter ATP-binding protein	-
JQN89_RS00390	69842..70732	-	891	WP_007056280.1	hypothetical protein	-
JQN89_RS00395	70729..71244	-	516	WP_032685213.1	hypothetical protein	-
JQN89_RS00400	71370..72065	+	696	WP_003829410.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	42857..82348	39491

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-87)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12650.60 Da
• Isoelectric Point: 9.1088

>T190111 WP_007056255.1 NZ_CP069278:c67576-67241 [Bifidobacterium longum]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI

Nucleotide

• Length: 336 bp

>T190111 NZ_CP091098:164901-165188 [Pantoea agglomerans]
ATGACCTGGCAACTGGAGTTCGATCAGAGGGCACTGAAAGAGTGGCGCAAGCTGGGCCCGACAGTACGTGAACAGCTTAA
AAAGAAGCTGGCTGAGTGTCTTGAGTCACCCAGAATTGAGGCGAACAAACTCAGCGGGATACCTGACTGCTATAAGATCA
AGCTAAAGTCATCCGGTTATCGACTTGTATACCAGGTTATTGATGACCGGGTGGTGGTTTTTGTGGTGGCTGTCGGGAAA
AGAGAGCGCTCAGAGGTCTGTTCTGCCGCCTCCAGGCGTCTCTCTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9844.16 Da
• Isoelectric Point: 4.5742

>AT190111 WP_007056990.1 NZ_CP069278:c67849-67580 [Bifidobacterium longum]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT190111 NZ_CP091098:164662-164901 [Pantoea agglomerans]
ATGGGCACAATTAACATTCGAATCGATGATGACCTGAAGACACGATCCTATGCTGCGCTCGAAAAAATGGGTGTGACTCC
CTCTGATGCGCTGCGCCTGATGCTTGAATATATTGCAGATAATGAACGTCTTCCTTTTAAGCAAACGTTACTCAGTGACG
AAGATGCGGCGTTAGTAGACATAGTTAAAGAACGCCTGCGAAACCCTGAGCCTGTCCGGGTCACACTGGATGACCTTTAA

Structures

Toxin

• AlphaFold DB: I3BGL7

Antitoxin

• AlphaFold DB: I3BGP0