Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2377854..2378824 Replicon chromosome
Accession NZ_CP069242
Organism Rhodococcus sp. USK13

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag JQT59_RS13595 Protein ID WP_213576572.1
Coordinates 2378234..2378824 (+) Length 197 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag JQT59_RS13590 Protein ID WP_213576571.1
Coordinates 2377854..2378237 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQT59_RS13565 2373118..2373447 + 330 WP_213576567.1 metalloregulator ArsR/SmtB family transcription factor -
JQT59_RS13570 2373447..2374148 + 702 WP_213576568.1 cation transporter -
JQT59_RS13575 2374191..2375186 - 996 WP_249354402.1 bile acid:sodium symporter -
JQT59_RS13580 2375372..2376235 - 864 WP_213576569.1 GNAT family N-acetyltransferase -
JQT59_RS13585 2376338..2377669 + 1332 WP_213576570.1 NAD(P)-binding domain-containing protein -
JQT59_RS13590 2377854..2378237 + 384 WP_213576571.1 hypothetical protein Antitoxin
JQT59_RS13595 2378234..2378824 + 591 WP_213576572.1 zeta toxin family protein Toxin
JQT59_RS13600 2378994..2379923 + 930 WP_213576573.1 ATP-binding cassette domain-containing protein -
JQT59_RS13605 2379920..2380732 + 813 WP_213576574.1 ABC transporter permease -
JQT59_RS13610 2381211..2381834 + 624 WP_213576575.1 sigma-70 family RNA polymerase sigma factor -
JQT59_RS13615 2381948..2382124 - 177 WP_162603283.1 hypothetical protein -
JQT59_RS13620 2382498..2382794 + 297 WP_213576576.1 SelT/SelW/SelH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-155)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-106)


Sequences

Toxin        


Download         Length: 197 a.a.        Molecular weight: 21753.77 Da        Isoelectric Point: 7.9934

>T190106 WP_213576572.1 NZ_CP069242:2378234-2378824 [Rhodococcus sp. USK13]
VKRLDLVVGCNGAGKSTFVALTLSPLLPAQPFVNADEIAKQRWPENPAAHSYDAAEIAAKTRTHLLALGKSFIAETVFSH
PSKLELIDEARTHEYTVVLHVVMIPEELAVQRVRYRVRAGGHDVPEDKIRQRYRRLWGLVAQAFPRCDHATVYDNSSITG
PRIVAQFTDGHLVGAATWPAWTPAELTSHTSRSEQL

Download         Length: 591 bp

>T190106 NZ_CP091095:c749005-748586 [Corynebacterium diphtheriae]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13590.06 Da        Isoelectric Point: 5.2078

>AT190106 WP_213576571.1 NZ_CP069242:2377854-2378237 [Rhodococcus sp. USK13]
MQSSADKVTRLAADLVASAMAEGERQHRTGRQQLEHWARVGRAVSSRQTAARRRVEDALAGRVPIGELGTEEGTVFNAEI
NAAIEEQLATAHYGTALAAQGITTVALSEDGQIVEYRPDGTHAVLPE

Download         Length: 384 bp

>AT190106 NZ_CP091095:c749616-749050 [Corynebacterium diphtheriae]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCACGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References